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Dr Angela Nobbs

Dr Angela Nobbs

Dr Angela Nobbs
B.Sc.(Manc.), Ph.D.(Bristol)

Senior Lecturer

Area of research

Mechanisms of streptococcal colonization and pathogenesis

Office UE-3-013
Lower Maudlin Street,
Bristol, BS1 2LY
(See a map)

+44 (0) 117 342 4508
+44 (0) 117 34 29494

Summary

Dr. Angela Nobbs is a Lecturer in Oral Microbiology within the School of Oral and Dental Sciences. Her research interests focus on the mechanisms by which Streptococcus bacteria are able to colonize and cause disease within the human host. These include determining the molecular basis of streptococcal interactions with other members of the oral microflora, such as the fungus Candida albicans, and with host epithelial and endothelial cells, in terms of adherence/invasion, biofilm formation and modulation of cell signalling responses.

Biography

Angela Nobbs received her Bsc (Hons) in Applied Microbiology at the University of Manchester in 1999. She was awarded a PhD in Molecular Microbiology at the University of Bristol in 2003, where her studies focused on streptococcal interactions with human epithelial cells and mechanisms of streptococcal colonization. This theme was continued with her first postdoctoral appointment at the University of Minnesota, where she worked on the role of streptococcal surface adhesins in mediating interbacterial competition, and on characterization of housekeeping transpeptidase sortase A. She then expanded this area to investigate the role of sortase A in pilus assembly by group B Streptococcus with a Marie Curie Fellowship at Novartis Vaccines, Siena. She returned to the University of Bristol in 2008 and was appointed Lecturer in Oral Microbiology in 2009. Current projects focus on the interactions of streptococci with the fungus Candida albicans, with host epithelial and endothelial cells, and on the impact of such interactions on microbial colonization and pathogenesis.

Activities / Findings

Recent research highlights include:

  • Identifying receptors on the surface of the fungus Candida albicans that enable intermicrobial interactions with oral bacterium Streptococcus gordonii
  • Determining the role of transpeptidase sortase A in the assembly of important colonization determinants, pili, on the surface of neonatal pathogen Streptococcus agalactiae (group B Streptococcus)
  • Identifying molecular recognition mechanisms by which oral streptococci are able to interact with host epithelial cells

Teaching

Undergraduate laboratory research projects are offered for dental students each Summer, and for BSc students undertaking degree programmes in Biochemistry, Microbiology, Medical Microbiology and Pathology and Microbiology each Winter. Vacation studentships sponsored by the Society for General Microbiology are also supervised within the Oral Microbiology Group laboratories.

Full- and part-time projects leading to MSc and PhD degrees by research are offered. For further details of these postgraduate opportunities, please refer to the Postgraduate Prospectus.

MSc project

MSc project

Keywords

  • Oral Microbiology
  • Dental Sciences
  • Microbial Adherence
  • Microbial Pathogenesis
  • Microbial Surface Proteins
  • Biofilms
  • Streptococcus
  • Candida albicans
  • Genetics of streptococci and Candida
  • Epithelial/endothelial cell interactions

Skills

  • Tonsillitis
  • Pharyngitis
  • Pneumonia
  • Meningitis
  • Septicaemia
  • Cardiovascular disease
  • Infective endocarditis
  • Atherosclerosis
  • Disseminated intravascular coagulation
  • Periodontitis
  • Gingivitis
  • Dental caries
  • Stomatitis
  • Candidosis

Processes and functions

  • Molecular microbiology
  • Cellular microbiology
  • Protein structure and function

Methodologies

  • Microbiology
  • Nucleic acid and protein sequence analyses
  • Microbial genetics
  • Electrotransformation
  • Protein purification
  • Biofilm models
  • Biological assays of adherence
  • ELISA
  • Fluorescence and confocal microscopy
  • Epithelial and endothelial cell culture
  • Microbial invasion assays
  • Cell signalling assays

Expertise

Defining the molecular mechanisms that enable bacterial colonisation of the host, focusing specifically on streptococci. Studies investigate the roles of bacterial surface proteins in a number of processes including: i) mediating adhesion to a variety of substrates ii) modulating host cell responses iii) influencing intermicrobial interactions, both competitive and co-operative

  • Streptococcus
  • surface proteins
  • intermicrobial interactions
  • Memberships

    Organisations

    Bristol Dental School

    Other sites

    Academic staff

    Research programmes

    Research groups

    Selected publications

    Read more >

    Recent publications

    View complete publications list in the University of Bristol publications system

    Networks & contacts

    • UoB - Howard Jenkinson
    • Dave Dymock
    • Mark Jepson
    • Jim Middleton

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