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Publication - Dr Andrea Waylen

    Selective drop-out in longitudinal studies and non-biased prediction of behaviour disorders

    Citation

    Wolke, D, Waylen, A, Samara, M, Steer, C, Goodman, R, Ford, T & Lamberts, K, 2009, ‘Selective drop-out in longitudinal studies and non-biased prediction of behaviour disorders’. British Journal of Psychiatry, vol 195., pp. 249 - 256

    Abstract

    Background

    Participant drop-out occurs in all longitudinal studies, and if systematic, may lead to selection biases and erroneous conclusions being drawn from a study.

    Aims

    We investigated whether drop out in the Avon Longitudinal Study of Parents And Children (ALSPAC) was systematic or random, and if systematic, whether it had an impact on the prediction of disruptive behaviour disorders.

    Method

    Teacher reports of disruptive behaviour among currently participating, previously participating and never participating children aged 8 years in the ALSPAC longitudinal study were collected. Data on family factors were obtained in pregnancy. Simulations were conducted to explain the impact of selective drop-out on the strength of prediction.

    Results

    Drop out from the ALSPAC cohort was systematic and children who dropped out were more likely to suffer from disruptive behaviour disorder. Systematic participant drop-out according to the family variables, however, did not alter the association between family factors obtained in pregnancy and disruptive behaviour disorder at 8 years of age.

    Conclusions

    Cohort studies are prone to selective drop-out and are likely to underestimate the prevalence of psychiatric disorder. This empirical study and the simulations confirm that the validity of regression models is only marginally affected despite range restrictions after selective drop-out.

    Full details in the University publications repository