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Professor Simon Satchell

Professor Simon Satchell

Professor Simon Satchell
M.B.B.S.(Lond.), Ph.D.(Bristol), M.R.C.P.(RCP), CCST Renal Medicine, CCST General Med

Professor of Renal and Vascular Medicine

Area of research

Glomerular endothelial cells and their contribution to the glomerular filtration barrier

Dorothy Hodgkin Building,
Whitson Street, Bristol BS1 3NY
(See a map)

Tel. +44 (0) 117 331 3086

Research summary

Glomerular endothelial cells (GEnC) form the innermost layer of the glomerular capillary wall which constitutes the glomerular filtration barrier. Normal GEnC possess numerous fenestrations, transcellular pores of 60-80nm in diameter. These fenestrations allow the high hydraulic conductivity of the glomerular filtration barrier, essential for filtration function. The surface of GEnC is, like other endothelial cells, covered by a glycocalyx. This also covers the fenestrations and contributes to the permeability barrier to macromolecules and hence to prevention of passage of albumin and other proteins into the urine.

We are working to understand in detail the contribution of GEnC to the glomerular ...

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Selected publications

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View complete publications list in the University of Bristol publications system

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