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Dr Shelley Allen-Birt

Dr Shelley Allen-Birt

Dr Shelley Allen-Birt
B.Sc.(Sur.)Hons 2:1, Ph.D.(Lond.)

Senior Lecturer in Medicine

Area of research

Neurotrophins and Neurodegeneration

Office 2.13
2nd Floor,
Learning and Research, Southmead Hospital BS10 5NB
(See a map)

Tel. +44 (0) 117 41 47901

Research summary

Our group is interested in the underlying molecular mechanisms of Alzheimer’s disease pathology. We have a series of linked projects into the production of amyloid, the genetic and environmental influences on this, and the early changes in Alzheimer brain, including changes in growth factors and their receptors.

NGF binding to TrkAIg2We are particularly interested in the tyrosine receptors TrkA and TrkB, and their respective ligands nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). NGF and BDNF are neurotrophic factors which support the connections between the cholinergic basal forebrain and the hippocampus. These are brain regions which are responsible for formation of new ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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