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Professor Seth Love

Professor Seth Love

Professor Seth Love
MBBCh(Witw.), PhD(London), MRCP/FRCP, MRCPath/FRCPath

Professor of Neuropathology

Area of research

Dementia Research

2nd Floor,
Learning and Research, Southmead Hospital BS10 5NB
(See a map)

+44 (0) 117 41 47819
+44 (0) 117 414 2412

Summary

Seth Love is Professor of Neuropathology, and together with  Professor Patrick Kehoe, leads the Dementia Research Group, a part of the Institute of Clinical Neurosciences. He is Director of the MRC UK Brain Bank Network and President of the International Society of Neuropathology. He is the lead editor of Greenfield's Neuropathology.

Professor Love's research concerns mechanisms of brain damage in dementia. His current projects are largely focused on understanding, quantifying and attempting to reverse vascular dysfunction in Alzheimer's disease and related causes of dementia, and on molecular interrelationships between Alzheimer's disease, Lewy body diseases and vascular dementia. This research is supported by the Medical Research Council, Alzheimer's Research UK, the Alzheimer's Society and BRACE (Bristol Research into Alzheimer's and Care of the Elderly).

Activities / Findings

Professor Love and his colleagues have developed a range of new biochemical methods to assess a range of aspects of vascular structure and function in human post-mortem brain tissue, including microvascular density, cerebral blood flow and vascular permeability. By applying these methods, they have shown that there is a pathological reduction on cerebral blood flow (i.e. a reduction exceeding the decline in metabolic demand) not only in vascular dementia but also in Alzheimer’s disease and Lewy body disease. Their work has highlighted the importance of the vasoconstrictor endothelin-1 in the very early reduction in cerebral blood flow in Alzheimer’s disease. They have shown that the vascular abnormalities are different in Lewy body disease, in which there is a failure of maintenance of small blood vessels by trophic factors, leading to a reduction in vascularity in the occipital cortex, a part of the brain often affected by reduced blood flow. Other activities of the group include research on the relationship between high blood pressure and dementia, vascular permeability, the removal of abnormal protein aggregates in Alzheimer’s disease and Lewy body disease, and interactions between different types of dementia at a molecular level.

Teaching

Teaching of neuropathology to Y2 and Y5 medical students; regular contributor to local, national and international neuroscience courses and seminars; member of the Pathology Education Program review panel of the International Network for Cancer Treatment and Research

Keywords

  • Apolipoprotein E
  • amyloid
  • ischaemia
  • blood-brain barrier

Skills

  • Alzheimer's disease
  • vascular dementia
  • dementia with Lewy bodies
  • cerebral amyloid angiopathy

Processes and functions

  • Mechanisms of neurodegeneration
  • oxidative stress
  • vascular function
  • cerebral blood flow
  • vascular permeability
  • Aβ clearance and degradation

Methodologies

  • Microscopy (including quantitative immunohistochemical techniques and confocal scanning laser microscopy)
  • protein biochemistry
  • enzyme assays
  • cell culture
  • gene expression studies

Expertise

My field of work is neuropathology, encompassing the analysis of brain tumours, muscle and nerve biopsies, cerebrospinal fluid cytology, and post-mortem brain examination. Most of my current research is in Alzheimer's disease and concerns the metabolism and clearance of soluble, insoluble and oligomeric forms of Abeta, alterations in Abeta-degrading enzymes, impairment of TGF-beta signal transduction, cerebral amyloid angiopathy, and vascular factors involved in the development of dementia. My research is supported by the Wellcome Trust, Medical Research Council, Engineering and Physical Sciences Research Council, Alzheimer's Research Trust, British Heart Foundation, Alzheimer's Society and BRACE (Bristol Research into Alzheimer's and Care of the Elderly).

  • neuropathology
  • Alzheimer's disease
  • Vascular dementia
  • Dementia with Lewy bodies
  • Links

    Recent publications

    View complete publications list in the University of Bristol publications system

    Networks & contacts

    • Dr Elizabeth Coulthard
    • Dr Hilary Archer
    • Dr Catherine Pennington (Dementia Neurology
    • Brain Centre
    • School of Clinical Sciences) Professor Steven Gill
    • Dr Alison Bienemann
    • Mr Neil Barua (Functional Neurosurgery
    • School of Clinical Sciences) Professor Julian Paton (Cardiovascular studies
    • School of Physiology and Pharmacology) Professor Scolding
    • Dr Alastair Wilkins and Dr Alan Whone (Academic Neurology
    • School of Clinical Sciences)

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