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Professor Sarah George

Professor Sarah George

Professor Sarah George
B.Sc., Ph.D.(Wales)

Professor of Cardiovascular Signalling

Area of research

Cardiovascular Signalling

Office Room 144
Level 7,
Bristol Royal Infirmary, Upper Maudlin Street BS2 8HW
(See a map)

Tel. +44 (0) 117 34 23154

Research summary

Coronary artery bypass surgery is a popular surgical technique used to treat patients with heart disease. The first coronary artery bypass was performed in 1960, but despite enhanced surgical techniques over the last 50 years, this surgery technique still requires improvement as the grafts themselves become diseased. Our research looks into the mechanisms underlying the failure of bypass grafts, by studying the behaviour of the smooth muscle cells in the graft.

We are currently examining a relatively unstudied area; the role of cell-cell contacts via cadherins in the regulation of smooth muscle cell behaviour and cardiovascular disease.

Our studies have ...

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Born in Bristol, Sarah Jane George graduated in Applied Biology from University of Wales in Cardiff in 1991. Following a PhD with Professor Andrew Newby at the University of Wales College of Medicine in Cardiff - entitled ‘Growth Factors and Smooth Muscle Cell Proliferation@ - she moved to the University of Bristol to carry out postdoctoral studies with Professor Gianni Angelini.  At this stage her studies centred on matrix degrading metalloproteinases and their inhibitors tissue inhibitors of metalloproteinases (TIMPs) particularly in the context of vein graft failure.

In the last 10 years she has undertaken a new area of research, the role of ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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