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Professor Saadeh Suleiman
Professor Saadeh Suleiman
Professor of Cardiac Physiology
PhD, DSc, FIACS, FRSB
Area of research
Cardiac Physiology & Myocardial Protection
Current research projects (basic science/translational/clinical):
- Role of cyclic AMP/PKA/Epac signalling in cardioprotection
- The Cardiac Role of the Exchange Protein Directly Activated by cAMP (Epac) During Postnatal Development
- Right VENtricle function in Children-RVENCH study
- The cardio-protective efficacy of cardioplegic solution supplemented with Sildenafil in neonatal pig model of cardiopulmonary bypass and cardioplegic arrest
- Selective S-nitrosation of mitochondrial complex I by MitoSNO as a new therapy for cardiac ischaemia-reperfusion injury
- A Polymeric Prosthetic Heart Valve from anisotropic nanocomposites– device optimisation and in vivo testing
- RIPC Clinical Trial: A two-centre randomised controlled trial investigating the effect of remote ischaemic preconditioning on biomarkers of stress and injury-related signalling in patients having isolated coronary artery bypass grafting or aortic valve replacement using cardiopulmonary bypass
- The role of cyclic-AMP/PKA/Epac signalling in cardioprotection of diseased heart (PhD project)
- The aged heart and diet: vulnerability to cardiac insults (PhD project)
- Cardiac survival signalling, oxidative stress & reperfusion injury during postnatal development (PhD project).
Completed my high school studies in Jerusalem in 1971. After spending 2 years at Bir Zeit College, I joined the American University in Beirut and was awarded a BSc in 1975. Obtained a PhD degree from the Universityof Essex in 1980. Joined the faculty of An-Najah University in Palestine (1980-1987) during which I held senior positions including Head of Biology and Dean of Research and served as a member of the Board of Directors for Scholarships at the British Council in Jerusalem. Joined Physiology Department at Bristol in 1988 and during the early 1990s helped to establish the Bristol Heart Institute. Awarded a DSc from Bristol in 2003 and was promoted to a Chair of Cardiac Physiology in the Faculty of Medicine & Dentistry in 2005. Prestigious activities include member of the team that was awarded the UK Hospital Doctor Award for Team of the Year in Surgery and runners up for Cardiovascular Medicine (2005), elected to the executive committee of the British Society for Cardiovascular Research (1998-2005) , elected Fellow of the International Academy of Cardiovascular Sciences (2010), elected Fellow of Society of Biology (2011), External Examiner for Medical & Veterinary Physiology, University of Cambridge (2010-2012) and for Medicine, University of Kuwait (2012-).
Undergraduate: Classes to 2nd & 3rd year Physiology students and to 2nd and 3rd year medical students. These include lectures, practical sessions, experimental projects, library projects & special study components.
Postgraduate: Unit Lead for Heart & Valve Disease within the MSc dgree in Tranlsational Cardiovascular Medicine. Seminars on Cardiopulmonary bypass, Cardioplegia, Ischaemia/Reperfusion, Cardiac conditioning, Inflammation and oxidative stress.
- Oxidative stress
- Calcium signalling
- High-fat diet
My research interests have been largely focused on understanding mechanisms that underlie cardiac injury in order to improve techniques of myocardial protection during open-heart surgery.
The following are specific areas of research:
1- Investigate the efficacy of different cardioplegic techniques during adult and paediatric open-heart surgery.
2- Characterise cardiac amino acid transporters and investigate their potential role in cardioprotection.
3- Investigate the role of mitochondrial pore inhibitors in protecting the immature heart during ischaemia and reperfusion.
myocardial protectioncardiac surgery techniquescardioplegiapaediatric open heart surgerycardiac amino acidsischaemia/reperfusion
- Caputo, M, Mokhtari, A, Miceli, A, Ghorbel, MT, Angelini, GD, Parry, AJ & Suleiman, SM 2014, Controlled reoxygenation during cardiopulmonary bypass decreases markers of organ damage, inflammation, and oxidative stress in single-ventricle patients undergoing pediatric heart surgery. The Journal of thoracic and cardiovascular surgery, vol 148., pp. 792-801.e8
- Zakkar, M, Ascione, R, James, AF, Angelini, GD & Suleiman, MS 2015, Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery. Pharmacology and Therapeutics.
- Littlejohns, B, Pasdois, P, Duggan, S, Bond, AR, Heesom, K, Jackson, CL, Angelini, GD, Halestrap, AP & Suleiman, M 2014, Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injury. PLOS ONE, vol 9., pp. e100579
- Khaliulin, I, Halestrap, AP, Bryant, SM, Dudley, DJ, James, AF & Suleiman, M 2014, Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion. Journal of Translational Medicine, vol 12., pp. 139
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- Iacobazzi, D, Suleiman, M-S, Ghorbel, M, George, SJ, Caputo, M & Tulloh, RM 2015, Cellular and molecular basis of RV hypertrophy in congenital heart disease. Heart.
- Pickard, JMJ, Bøtker, HE, Crimi, G, Davidson, B, Davidson, SM, Dutka, D, Ferdinandy, P, Ganske, R, Garcia-Dorado, D, Giricz, Z, Gourine, AV, Heusch, G, Kharbanda, R, Kleinbongard, P, MacAllister, R, McIntyre, C, Meybohm, P, Prunier, F, Redington, A, Robertson, NJ, Suleiman, MS, Vanezis, A, Walsh, S, Yellon, DM & Hausenloy, DJ 2015, Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop. Basic Research in Cardiology, vol 110., pp. 453
- Abdul-Ghani, S, Heesom, KJ, Angelini, GD, Suleiman, M-S & Suleiman, M 2014, Cardiac phosphoproteomics during remote ischemic preconditioning: a role for the sarcomeric Z-disk proteins. BioMed research international, vol 2014.
- Bryant, S, Kimura, TE, Kong, CHT, Watson, JJ, Chase, A, Suleiman, MS, James, AF & Orchard, CH 2014, Stimulation of ICa by basal PKA activity is facilitated by caveolin-3 in cardiac ventricular myocytes. Journal of Molecular and Cellular Cardiology.
- Littlejohns, B, Lin, H, Angelini, GD, Halestrap, AP & Suleiman, MS 2014, Switching Back to Normal Diet Following High-Fat Diet Feeding Reduces Cardiac Vulnerability to Ischaemia and Reperfusion Injury. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, vol 34., pp. 1090-1100
- Littlejohns, B, Heesom, K, Angelini, GD & Suleiman, M-S 2014, The effect of disease on human cardiac protein expression profiles in paired samples from right and left ventricles. Clinical proteomics, vol 11., pp. 34
Networks & contacts
- Bristol: Gianni Angelini Andrew Halestrap Raimondo Ascione Massimo Caputo Andrew James Clive Orchard Mo Ghorbel Mervyn Miles
Overseas:Andrea Venturini (Italy) Hajime Imura (Japan) Nicola King (Australia) Malcolm Underwood (Hong Kong) Chris Howarth (UAE) Camille Nassar (Lebanon)
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