♥ Design novel cardio-protective strategies
♥ Investigate cardiac cellular/molecular remodelling during coronary disease and/or high-fat diet feeding
♥ Oxidative stress and excitation-contraction coupling in cardiomyocytes during postnatal development
♥ Use of atomic force microscopy to investigate the viscoelasticity of isolated cardiomyocytes
♥ Cellular/molecular remodelling in cardiac chambers and during cardioplegic arrest in adult and paediatric patients undergoing open heart surgery
♥ Cardioprotection with propofol during adult open heart surgery
♥ Cardioprotective action of mitochondrial targeted anti-oxidants and following remote conditioning
♥ Efficacy of Custodiol cardioplegia during mitral valve surgery
Completed my high school studies in Jerusalem in 1971. After spending 2 years at Bir Zeit College, I joined the American University in Beirut and was awarded a BSc in 1975. Obtained a PhD degree from the Universityof Essex in 1980. Joined the faculty of An-Najah University in Palestine (1980-1987) during which I held senior positions including Head of Biology and Dean of Research and served as a member of the Board of Directors for Scholarships at the British Council in Jerusalem. Joined Physiology Department at Bristol in 1988 and during the early 1990s helped to establish the Bristol Heart Institute. Awarded a DSc from Bristol in 2003 and was promoted to a Chair of Cardiac Physiology in the Faculty of Medicine & Dentistry in 2005. Prestigious activities include member of the team that was awarded the UK Hospital Doctor Award for Team of the Year in Surgery and runners up for Cardiovascular Medicine (2005), elected to the executive committee of the British Society for Cardiovascular Research (1998-2005) , elected Fellow of the International Academy of Cardiovascular Sciences (2010), elected Fellow of Society of Biology (2011), External Examiner for Medical & Veterinary Physiology, University of Cambridge (2010-2012) and for Medicine, University of Kuwait (2012-).
Undergraduate: Classes to 2nd & 3rd year Physiology students and to 2nd and 3rd year medical students. These include lectures, practical sessions, experimental projects, library projects & special study components.
Postgraduate: Unit Lead for Heart & Valve Disease within the MSc dgree in Tranlsational Cardiovascular Medicine. Give Seminars on Cardiopulmonary bypass, Cardioplegia, Ischaemia/Reperfusion, Cardiac conditioning, Inflammation and oxidative stress.
My research interests have been largely focused on understanding mechanisms that underlie cardiac injury in order to improve techniques of myocardial protection during open-heart surgery. The following are specific areas of research: 1- Investigate the efficacy of different cardioplegic techniques during adult and paediatric open-heart surgery. 2- Characterise cardiac amino acid transporters and investigate their potential role in cardioprotection. 3- Investigate the role of mitochondrial pore inhibitors in protecting the immature heart during ischaemia and reperfusion.
View complete publications list in the University of Bristol publications system
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