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Professor Andrew Dick

Professor Andrew Dick

Professor Andrew Dick
B.Sc., M.B.B.S.(Lond.), M.D.(Aberd.), M.R.C.P.(UK), F.R.C.S.(Lond.), F.R.C.S.(Edin.), F.R.C.P.(Edin.), F.R.C.Ophth, FMedSci

Professor of Ophthalmology

Area of research

Immune mechanisms of autoimmune disorders of the eye

Ophthalmology,
Bristol Eye Hospital, Lower Maudlin Street BS1 2LX
(See a map)

+44 (0) 117 342 4854

Summary

Group: Inflammatory Eye Disease Group

My group's work and that of others in ophthalmology focuses on how the retina responds to injury, inflammation and degeneration. This covers areas which include:

  1. The control of immune responses in the retina which includes for example the interaction with microglia and inhibitory signals mediated by neuronal CD200 expression
  2. Autoimmune responses within the eye and brain, by studying both T cell and macrophage responses within the tissue during experimental retinal and CNS autoimmunity
  3. Microglial and macrophage behaviour during retinal degeneration by studying experimental models of photoreceptor degeneration
  4. Retinal remodelling by studying the interaction of microglia, Muller cells and retinal progenitor cells
  5. Role of macrophages in retinal and choroidal angiogenesis
  6. Development of immunomodulatory agents for the treatment of uveitis, investigated in the experimental model of uveitis

Clinically we are undertaking significant advances in human ocular immunology through both our lead of Inflammation and immunotherapeutics of Biomedical Research Centre at Moorfields Eye Hospital and UCL-Institute of Ophthalmology. This includes:

(i) proof of concept early phase trials of immunotherapeutics.

(ii) Understanding of immune responses via live in vivo imaging of leukocytes through the retinal and choroidal vasculature in man.

(iii) progressing with development of gene therapy for treatment of uveitis

 Present collaborators

  • Dr Lindsay Nicholson, Schoool of Cellular and Molecular Medicine
  • Dr Richard Lee, School of Clinical Sciences
  • Dr Denize Atan, School of Clinical Sciences
  • Dr Bob Nussenblatt, National Eye Institute, USA
  • Professor R Ali, Institute of Ophthalmology and Institute of Child Health, UCL
  • Professor John Forrester, University of Aberdeen
  • Professor Jim Bainbridge, Institute of Ophthalmology, UCL
  • Professor Mike Boulton, Indiana University School of Medicine

Activities / Findings

  • Role of neuronal CD200 in control of myeloid activity within retina
  • Progenitor cell differentiation in adult human retina
  • Mechanisms of microglial-mediated immune regulation
  • Role of Microglia during retinal degeneration
  • Mechahism of macrophage-induced retinal damage during inflammation

Teaching

MSc project

Keywords

  • autoimmunity
  • macrophages
  • microglia
  • progenitor cells

Skills

  • Uveitis
  • Retinitis pigmentosa
  • diabetes
  • retinal detachment

Processes and functions

  • Autoimmunity
  • angiogenesis
  • tissue repair

Methodologies

  • Cell culture
  • Western
  • PCR
  • FACS
  • immunohistochemistry
  • ELISA

Expertise

Immune mechanisms of autoimmune disorders of the eye. The ophthalmic-immunology group's work focuses on how the retina responds to injury, inflammation and degeneration. This covers areas which include: -The control of immune responses in the retina which includes the interaction with microglia and inhibitory signals mediated by neuronal CD200 expression and matrix (TSP). -The myeloid cell control of angiogenesis during wound healing and chronic inflammation. -Autoimmune responses within the eye and brain, by studying both T cell and macrophage responses within the tissue during experimental retinal and CNS autoimmunity. -Microglial and macrophage behaviour during retinal degeneration by studying experimental models of photoreceptor degeneration. -Retinal remodelling by studying the interaction of microglia, Muller cells and retinal progenitor cells. -Development of immunomodulatory agents for the treatment of uveitis, investigated in the experimental model of uveitis. - Clinical trials for inflammatory eye disease and retinal diseases such as Age related macular degeneration

  • autoimmunity
  • retinal neural progenitor cell research
  • graft rejection
  • macrophages
  • microglia
  • uveitis
  • Retinal disease
  • Recent publications

    View complete publications list in the University of Bristol publications system

    Networks & contacts

    • Professor R Ali
    • Institute of Ophthalmology and Institute of Child Health
    • UCL
      Dr Jon Sedgwick
    • DNAX
    • California
    • USA
      Professor John Forrester
    • University of Aberdeen
      Dr Neil Williams
    • Department of Pathology and Microbiology
    • Bristol
      Professor David Wraith
    • Department of Pathology and Microbiology
    • Bristol
      Professor John Isaacs
    • University of Newcastle
      Professor Dave Shima
    • UCL

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