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Professor Patrick Kehoe

Molecular Epidemiology and Translational Research into Dementia therapeutics

Together with Professor Seth Love, I jointly head the Dementia Research Group, a part of the Institute of Clinical Neurosciences, and the School of Clinical Sciences

My main research interest for over a decade has investigated mechanisms that may underlie the widely acknowledged, but still poorly understood, association between hypertension and blood pressure regulation with respect to the development of Alzheimer’s disease (AD) and other dementias. Of particular interest is the role of the renin angiotensin system (RAS) in the pathology of AD. This increasingly appears to be multifunctional in its associations with many of the pathological pathways recognised in AD including cerebral blood flow reductions, inflammation, neurotransmitter imbalances and oxidative stress. We are currently leading on a multi-site clinical trial (RADAR) of a RAS-acting drug losartan in Alzheimer’s disease. This is based on earlier work we have undertaken on the RAS has also served as a template for other investigations into the behaviour and involvement in AD and other dementias of other related vasomodulatory enzymes such neprilysin, insulin-degrading enzyme and endothelin-converting enzymes.

My other areas of interest include the aetiology of various forms of Vascular Cognitive Impairment (VCI). We undertake research to try and identify genetic risk factors for VCI, potential synergies with genetic risk factors for stroke, but also to undertake research to harmonise the conceptualisation and classification of different forms of VCI.

The Dementia Research Group has a multidisciplinary and applied approach to the investigation of the neuropathology of Alzheimer's disease. This includes the use of genomic and various proteomic/metabolomic approaches further supported by additional molecular biological, cell culture in conjunction with histological and immunohistochemical approaches that are largely underpinned by tissue from the South West Dementia Brain Bank (SWDBB) or Brains for Dementia Research.

Research keywords

  • Amyloid
  • Angiotensin
  • Clinical Trials
  • Dementia
  • Gene
  • Immunohistochemistry
  • Neuropathology
  • Pharmacoepidemiology
  • Tau

Diseases related to this field of research

  • Alzheimer's disease
  • Cerebral Amyloid Angiopathy
  • Dementia
  • Hypertension
  • Vascular Cognitive Impairment
  • Vascular Dementia

Processes and functions relevant to this work

  • Memory and cognitive function
  • Gene variation
  • Enzyme activity

Collaborations

  • Various members from a number of Alzheimer’s Research UK Network Centres
  • Members of the European Alzheimer's Disease Consortium (EADC)