Browse/search for people

Professor Massimo Caputo

Professor Massimo Caputo

Professor Massimo Caputo
M.D.(Naples), M.Ch.(Bristol)

Professor of Congenital Heart Surgery

Area of research

Cardiac Surgery

Office Room 83
Level 7,
Bristol Royal Infirmary, Upper Maudlin Street BS2 8HW
(See a map)

+44 (0) 117 34 28857
+44 (0) 117 3428854


Research Interests:


  • Transcriptomics and proteonomics in congenital heart disease
  • Identifying the optimal stem cell populations for vascular tissue regeneration used in congenital heart surgery
  • Regenerative stem cell biology for children with heart failure
  • Pulmonary hypertension
  • Bicuspid aortic valve and Marfan syndrome
  • Effect of oxidative stress in cardiomyocytes during different stages of postnatal development
  • The role of mitochondria in increased vulnerability to cardiac insults of hearts and cardiomyocytes isolated from mice fed Western style high-fat diet
  • The role of ventricular arrhythmias in sudden death associated with coronary artery disease
  • Effect of oxidative stress and the role of mitochondria in hearts with chronic coronary artery disease
  • The role of amino acids in cardioprotection
  • Lung protection in cardiopulmonary bypass and cardioplegic arrest


  • Improving myocardial protection strategies in paediatric cardiac surgery
  • RCTs on different temperature and oxygen strategies during CPB in children undergoing cardiac surgery (Thermic and Oxic Trials)
  • Imaging and outcomes in adult congenital heart disease
  • Atrial arrhytmias in adult and congenital cardiac diseases
  • Age-related changes in excitation-contraction coupling in paediatric cardiomyocytes
  • Cardioprotection with propofol during adult open heart surgery

Current group members

  • Mohamed Ghorbel, Hua Lin, Sarah Martin, Jihad Hawi, Ben Littlejohns, Simon Duggan


  • UK
    Gianni Angelini, Paolo Madeddu, Andrew Halestrap, Elinor Griffiths, Raimondo Ascione, Jamie Jeremy, Barney Reeves, Andy James, Clive Orchard, Jules Hancox, Mervyn Miles, Claire Stewart.
  • Overseas
    Andrea Venturini (Italy), Hajime Imura (Japan), Nicola King (Australia), Malcolm Underwood (Hong Kong), Chris Howarth (UAE), Camille Nassar (Lebanon).



Date of Birth  02.05.1968

Nationality    Italian                         


April 2017 British Heart Foundation Chair in Congenital Cardiac Surgery,

Bristol Heart Institute/Bristol Royal Hospital for Children NHS Foundation Trust; School of Clinical Sciences, University of Bristol.

This is a full-time clinical academic appointment with a 50:50 clinical:research split. My clinical interests include neonatal surgery, complex aortic surgery in young adults, minimally invasive pulmonary valve surgery, mitral and tricuspid valve repair. I perform over 200 complex major cardiac procedures per year. My 30 day mortality rates have been constantly below 1-2%

April 2014-September 2015: I was recruited and seconded to set up the Congenital Heart Surgery Program at the RUSH University Medical Center in Chicago, where I have been appointed Director of Congenital Heart Surgery.



2012-2017 Professor of Congenital Cardiac Surgery,

Bristol Heart Institute/Bristol Royal Hospital for Children NHS Foundation Trust; School of Clinical Sciences, University of Bristol

2008-2012 Reader/Consultant in Cardiothoracic Surgery, Bristol Heart Institute/Bristol Royal Hospital for Children NHS Foundation Trust, University of Bristol.

2004-2008 Senior Lecturer/Consultant in Cardiothoracic Surgery, Cardiac, Anaesthetic and Radiological Sciences, Bristol Royal Infirmary, University of Bristol.

2003-2004 Attending Surgeon in Paediatric Surgery, Thorax Centre, University of Leiden, The Netherlands.

2000-2003 Senior Registrar/Lecturer, Cardiac, Anaesthetic and Radiological Sciences, Bristol Royal Infirmary, University of Bristol.

1998-2000 Staff Surgeon (Senior Registrar Level), Dept. of Cardiac Surgery, University Hospital “San Raffaele”, Milan.

1995- 1997  Clinical Research Fellow, Bristol Heart Institute,University of Bristol.

1992-1998 Specialist Trainee in Cardiac Surgery, Dept. of Cardiac Surgery, University Federico II, Naples.


Jan  2006        Honorary Fellow of the Royal Collage of Surgeons of England (FRCS)

May 2003       GMC Specialist Registration in Cardio-Thoracic Surgery

May 2000       Master of Surgery (MCh)

University of Bristol, UK

Thesis on: “The Effects of Different Techniques of Myocardial Protection on the Myocardial Concentrations of Amino Acids in the Ischaemic-Reperfused Heart of Patients Undergoing Coronary Artery Surgery”

March 1998    Specialization in Cardiac Surgery (Final Exam)

University of Naples, Italy, March 1998

Thesis on: “Intermittent Antegrade Warm Blood Cardioplegia in Patients Undergoing Coronary Artery Surgery: a Prospective Randomized Study on the Use of Magnesium”.

July 1992       Medical Doctorate (MD)

University of Naples, Italy, July 1992

Thesis on: “The Use of the Internal Mammary Arteries in Myocardial Revascularization”.

June 1992      Degree in Medicine and Surgery

University-Hospital “Federico II”, Medical School, Naples, Italy (1986-1992).


2018                Silver Clinical Excellence Award (National Clinical Excellence Award Scheme, UK)

2018                Visiting Professor Paediatric Cardiac Surgery Unit, University of Nablus, Palestine.

2017                BHF Chair in Congenital Heart Surgery

2015                Lead for Cardiac Surgery (Bristol Cardiovascular)

2015                Bronze Clinical Excellence Award (National Clinical Excellence Award Scheme UK)

2015                Sir Jules Thorn Award for Biochemical Research (£1.5M).

2014               Visiting Professor at the Rush University Medical Centre, Chicago, USA.

2012               John Parker Medal, Annual Meeting of the Society for Cardiothoracic Surgery Great Britain and Ireland, London

2011               John Parker Medal, Annual Meeting of the Society for Cardiothoracic Surgery Great Britain and Ireland, London.

2011                Honorary Member, Syrian British Medical Society.

2008                Chief Surgeon for the charity “Al-Dir Charity Hospital” to establish the congenital cardiac surgical program at the Homs University, Syria.

2006                Honorary  Surgeon for the charity “Cardiostart” to perform adult and paediatric cardiac surgery in Arequipe, Peru.

2005                Member of the BRI Team winner of the “Hospital Doctor Award 2005” (for Surgery) for the work on beating heart coronary surgery.

2004                Visiting Professor Paediatric Cardiac Unit, University of West Indies, Trinidad and Tobago.

2004                Garfield Weston Senior Lecturer Fellowship (2004-2009)

2004                Travelling Fellowship to work at the Paediatric Cardiac Surgical Unit, University of Leiden, The Netherlands.

1999-               Visiting Teacher at the annual “International Heart School J.W.Kirklin”, Bergamo, Italy.

1998                Travelling Fellowship to work at the Dept. of Cardio-Thoracic Surgery for a month, University of Groningen, The Netherlands.

1998                Distinction (60/60 cum laude), Specialist in Cardiac Surgery, University of Naples, Italy.

1992                MD, Distinction (110/110 cum laude), Final Examination, University of Naples, Italy.

1991                Winner of ERASMUS/ECTS European Community Grant, University of Manchester, UK.

1990                Winner of ERASMUS/ECTS European Community Grant, University of Bristol, UK.

1989                Winner of ERASMUS European Community Grant, Universite’ Catolique de Louven, Belgium.


I am recognised expert in several fields of cardiac surgery and I have given invited lectures on these topics at national and international meeting, educational seminars and postgraduate courses.  This includes being a faculty member on the Bristol Training Course in Cardiac Surgery, the Human Disease Course, the Paediatric Ground Round Program and the Bristol Paediatric Simulation Programme. In 2000 I was appointed to a Visiting Teacher position at the International Heart School “J W Kirklin” in Bergamo, Italy.  This is now recognised as the European School for Cardio-Thoracic Training. I am routinely involved in the preparation of monthly audits meetings for the Cardiothoracic Services at the Bristol Royal Hospital for Children and the Bristol heart Institute, and the junior doctors training for the Fellowship Examination. I am also the supervisor for Research Registrars with projects for Higher Degree thesis.

I have developed a monitoring system for assessing performance new surgical techniques, which greatly facilitate the auditing and constant monitoring of the results. This work has been widely published and has become fundamental in monitoring the training process of our specialist registers as well as the consultants in learning new surgical techniques.

Since January 2000, I have been involved as the chief surgeon, in the development of the Paediatric Cardiac Unit at the University of West Indies in Trinidad and Tobago, teaching local doctors and nurses, and since March 2006 I am an honorary surgeon for the International Compassionate Medical Assistance “CardioStart”, participating in a clinical and educational mission in Peru.

Since September 2009 I have started a video assisted anatomical course on the most common congenital abnormalities with videos recorded by myself of the most important surgical procedures performed at the Bristol Royal Hospital for Children. The lectures are run together with a cardiologist (for the pre-operative investigations) and have been greatly successful. The web site with all these interactive lectures is being developed:

Since 2010 I have also been appointed as surgical adviser for congenital heart surgery at the Bristol Medical Simulation Centre.

I act as external reviewer to several UK and European Universities for undergraduate and post-graduate degrees and Unit Assessment.

Since 2013 I am the teaching leader for the congenital heart disease theme for the MSc in Translational Cardiovascular Medicine at the University of Bristol.

Since April 2014 I have been nominated academic mentor for the CardioThoracic and Vascular Residency Program at the Rush University Medical Center.


  • Congenital
  • Heart
  • Surgery


My scientific research focuses on the development of techniques of myocardial protection in adult and paediatric surgery. My research involving basic science and clinical studies aims to analyse the impact of different strategies of myocardial protection on ischaemia and reperfusion injury. My work had drastically changed the myocardial protection protocol of the Unit, with a switch from cold crystalloid to warm blood cardioplegic techniques. In the last two years, I have turned my interest into the improvements of myocardial protection strategies in paediatric heart surgery. In particular I have been studying the impact of age and cyanosis on myocardial protection, and the pathology related differences that exist in congenital heart surgery. I have also been a key figure in the development of off pump coronary surgery and in the assessment of its safety and efficacy in clinical practice.

  • myocardial protection
  • ischaemia
  • reperfusion injury
  • heart surgery
  • pump coronary surgery
  • Memberships


    Bristol Medical School (THS)

    Other sites

    Academic staff

    Recent publications

    View complete publications list in the University of Bristol publications system

    Edit this profile If you are Professor Massimo Caputo, you can edit this page. Login required.

    PDF versionDownload PDF