Professor Marianne Thoresen

Research summary

Worldwide, newborn infants suffer death or permanent brain damage caused by diseases arising before or around the time of birth. I do translational research aimed at developing effective treatment. By integrating my studies of normal physiological changes in many organ systems with pathological changed seen during disease, I have -together with my students - developed experimental models that mimic global hypoxic-ischemic injury and brain haemorrhage leading to permanent disability in children. The neuroprotective effect of cooling newborns first presented in these models led to international clinical trials where we documented the same neuroprotective effect in humans that were cooled and this ...

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Links

•   www.thoresen.org.uk

Recent publications

• Sabir, H, Dingley, J, Scull-Brown, E, Chakkarapani, E & Thoresen, M, 2018, ‘Fentanyl induces cerebellar internal granular cell layer apoptosis in healthy newborn pigs’. Frontiers in Neurology.
• Falck, M, Osredkar, D, Maes, E, Flatebø, T, Wood, T, Walløe, L, Sabir, H & Thoresen, M, 2018, ‘Hypothermia is Neuroprotective after Severe Hypoxic-Ischaemic Brain Injury in neonatal rats pre-exposed to PAM3CSK4’. Developmental Neuroscience.

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View complete publications list in the University of Bristol publications system