Professor Marianne Thoresen

Research summary

Worldwide, newborn infants suffer death or permanent brain damage caused by diseases arising before or around the time of birth. I do translational research aimed at developing effective treatment. By integrating my studies of normal physiological changes in many organ systems with pathological changed seen during disease, I have -together with my students - developed experimental models that mimic global hypoxic-ischemic injury and brain haemorrhage leading to permanent disability in children. The neuroprotective effect of cooling newborns first presented in these models led to international clinical trials where we documented the same neuroprotective effect in humans that were cooled and this ...

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Links

•   www.thoresen.org.uk

Recent publications

• Chakkarapani, E, Dingley, J, Aquilina, K, Osredkar, D, Liu, X & Thoresen, M 2013, ‘Effects of xenon and hypothermia on cerebrovascular pressure reactivity in newborn global hypoxic-ischemic pig model’. Journal of Cerebral Blood Flow and Metabolism, vol 33., pp. 1-9
• Thoresen, M, Tooley, J, Liu, X, Jary, S, Fleming, P, Luyt, K, Jain, A, Cairns, P, Harding, D & Sabir, H 2013, ‘Time Is Brain: Starting Therapeutic Hypothermia within Three Hours after Birth Improves Motor Outcome in Asphyxiated Newborns’. Neonatology, vol 104., pp. 228-233

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View complete publications list in the University of Bristol publications system