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Dr Konstantinos Kalafatakis

Dr Konstantinos Kalafatakis

Dr Konstantinos Kalafatakis
MD, MSc, PhD

Honorary Research Fellow

Area of research

Glucocorticoid pulsatility and brain physiology & pathology

Dorothy Hodgkin Building,
Whitson Street, Bristol BS1 3NY
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Summary

 

Biography

I graduated from the German School of Athens in 2004. I have received my Medical degree (M.D.) from the University of Athens, Greece, my Master of Science degree (M.Sc.) on Neuroimaging for Research from the University of Edinburgh, UK, and my Doctorate in Philosophy (Ph.D.) for the University of Bristol, UK. My clinical research focuses on the effects of different systemic glucocorticoid dynamics in the human brain under physiological and pathological conditions. In the past (2009-13), I was involved in preclinical neuroscientific research in the departments of Physiology and Pharmacology of the Medical School in the University of Athens. I have published around 20 papers in peer-reviewed biomedical journals, participated with around 20 presentations in national and international scientific meetings/ congresses, as well as given lectures within the undergraduate curriculum of the Medical School, University of Athens (topic: Physiology of Ageing). I am a member of the General Medical Council (GMC), British Neuroscience Association (BNA), Academy of Pharmaceutical Sciences (APS), European College of Neuropsychopharmacology (ECNP) and the Royal Society of Biology (RSB). 

Activities / Findings

Accumulating evidence over the past decades support the pathogenic interaction of the genetic background of susceptible individuals with chronic imbalances of the stress system, towards the development of neuropsychiatric disease, particularly neurodegeneration and mood disorders. We have very recently shown that different ultradian glucocorticoid rhythms change the resting state neural dynamics of the human brain, and differentially modulate mood, quality of sleep, working memory, and the neural processing and the behavioural responses to emotional input, reflecting variations in the susceptibility towards neuropsychiatric patholog. These findings may be particularly important for glucocorticoid-based therapeutics, which modify the normal ultradian rhythm of the hormone, and may thus render affected individuals prone to brain disease. 

Keywords

  • Glucocorticoids
  • pulsatility
  • human brain
  • replacement therapy

Skills

  • Depression
  • Neurodegeneration
  • Adrenal insufficiency
  • Neurotoxicity

Processes and functions

  • Clinical trials
  • Functional neuroimaging
  • Cognitive/Behavioural testing

Methodologies

  • Brain MRI (Magnetic Resonance Imaging)

Recent publications

View complete publications list in the University of Bristol publications system

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