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Dr Jason Johnson

Dr Jason Johnson

Dr Jason Johnson
MSc, PhD

Senior Research Fellow

Area of research

Atherosclerosis

Office Room 85
Level 7,
Bristol Royal Infirmary, Upper Maudlin Street BS2 8HW
(See a map)

+44 (0) 117 34 23583

Summary

Expertise

My research focuses on atherosclerosis ? the build up of fatty material on the lining of arteries to form ?plaques? that can partially block the artery and reduce blood flow. Heart attacks and strokes are primarily caused by cracking of these plaques. Exactly what causes the plaques to rupture is not known, and forms the basis of my Fellowship. The fatty material forming the plaque (blockage) consists of different types of cell, and one type of cell, macrophages, may contribute not only to plaque formation, but also to their cracking. The macrophages exist in several forms that are both good and bad with respect to plaque formation and cracking. Bad macrophages have an increased capacity to grow and divide into more cells, increasing the size of the plaque, but may also trigger death of smooth muscle cells that normally stabilise plaques. The bad macrophages ?destabilise? the plaques, and promote cracking.

  • atherosclerosis
  • Memberships

    Organisations

    Bristol Medical School (THS)

    Other sites

    Academic staff

    Recent publications

    View complete publications list in the University of Bristol publications system

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