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Professor Hans Reul

Professor Hans Reul

Professor Hans Reul
PhD(Utrecht)

Professor of Neuroscience

Area of research

Epigenetics of stress-related learning and memory

Dorothy Hodgkin Building,
Whitson Street, Bristol BS1 3NY
(See a map)

+44 (0) 117 331 3137

Summary

My research group investigates how the organism responds and adapts to stressful events.

Major research interests are:

  1. The signalling, epigenetic and genomic mechanisms in the brain underlying stress-related learning and memory processes.

  2. The regulation of the hypothalamic-pituitary-adrenal (HPA) axis under baseline and stress conditions.

  3. The physiological and neurobiological mechanisms underlying the beneficial effects of voluntary exercise on stress coping, HPA axis regulation, and anxiety-related and cognitive behaviour.

Expertise

My research group investigates how the organism responds and adapts to stressful events. The emphasis is on how we learn and form memories of emotionally stressful events in our lives so we can respond better if such events should reoccur.

Our research programme addresses the role of signalling, epigenetic and genomic processes in the brain in the consolidation of adaptive behavioural responses and memory. Furthermore, we are investigating the role of adult neurogenesis in the dentate gyrus in these processes and responses.

Behavioural responses and memory formation are investigated in the forced swim test, Morris water maze learning and contextual fear conditioning. Our neuroanatomical and molecular expertise includes immuno-fluorescence analysis, lentiviral technology (in collaboration with Professor James Uney (UoB)) and state-of-the-art epigenetic methods such as chromatin-immuno-precipitation (nChIP, xChIP), next generation Illumina sequencing and bisulfite sequencing (in collaboration with Dr. Jon Mill, King’s College London).

Teaching

Unit Director of Unit 6 "Integrative Molecular Neuroscience" in MSc Molecular Neuroscience at HW-LINE (click here for course details).

Unit Director of Unit 7 "Research Project" in MSc Molecular Neuroscience at HW-LINE (click here for course details).

Keywords

  • stress
  • learning and memory
  • epigenetics
  • signalling pathways
  • hypothalamic-pituitary-adrenocortical axis
  • glucocorticoid hormone
  • neurogenesis
  • behaviour
  • exercise

Skills

  • Major Depression
  • Anxiety
  • Post-traumatic stress disorder (PTSD)

Processes and functions

  • neuronal plasticity
  • intracellular signalling pathways
  • chromatin remodelling
  • gene transcription
  • Hypothalamo-pituitary-adrenal (HPA) axis regulation
  • behavioural adaptation
  • learning and memory

Methodologies

  • Immunohistochemistry
  • In situ hybridisation
  • stress tests
  • behavioural tests
  • radioimmunoassays
  • microdialysis (in collaboration with Professor Astrid C.E. Linthorst)

Expertise

My research group investigates how the organism responds and adapts to stressful events. Major research interests are: ? The mechanisms of regulatory control of the hypothalamic-pituitary-adrenocortical axis at the brain and adrenal level, including the role of limbic/neocortical centres and the autonomic nervous system ? The role of glucocorticoid hormones, the MAPK pathway and other signalling pathways in neuronal plasticity processes (e.g. chromatin remodelling, transcriptional activation) and behavioural adaptation ? The mechanisms underlying the beneficial effects of (voluntary) exercise on stress coping, HPA axis regulation, autonomic control, impulsivity and anxiety-related behaviour

  • stressful events
  • stress
  • hypothalamic-pituitary-adrenocortical axis
  • autonomic nervous system
  • glucocorticoid
  • signalling pathways
  • Recent publications

    View complete publications list in the University of Bristol publications system

    Networks & contacts

    • Dr Jonathan Mill - King's College London
    • Professor James Uney - University of Bristol
    • Professor Astrid C.E. Linthorst - University of Bristol
    • Professor Lou Muglia - Washington University St Louis USA
    • Professor David Nutt - Imperial College London

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