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Professor Gianni Angelini

Professor Gianni Angelini

Professor Gianni Angelini
M.D.(Sienna), M.Ch.(Wales), F.R.C.S.(Glas), FETCS

BHF Professor of Cardiac Surgery and Director

Area of research

Cardiac Surgery

Office Room 81
Level 7,
Bristol Royal Infirmary, Upper Maudlin Street BS2 8HW
(See a map)

+44 (0) 117 34 23165


The overall goal of my research is to optimise the benefits of cardiac surgery on the heart and patient, while reducing the traumatic effects. Specific areas include:

Adult and Paediatric Cardiac Surgery
Clinical studies and trials to reduce myocardial injury and inflammation during adult cardiac surgery, and reperfusion injury in cyanotic children with congenital heart disease. We also try to reduce the inevitable adverse effects of surgical trauma and cardiopulmonary bypass, e.g. by comparing thoracotomy vs. sternotomy for off-pump coronary coronary artery bypass (OPCAB) surgery, warm vs. cold-blood cardioplegia in on-pump coronary and valve surgery, general anaesthesia with high thoracic epidural vs. general anaesthesia alone, and reduced vs. conventional cross-clamp time in combined coronary and valve surgery.

Angiogenesis and regenerative medicine
Using adult vascular progenitor cells, both for use as cardiovascular biomarkers, and for improving therapies in the clinic.

Carrying out preclinical studies and, subsequently, the first-in-man trials of drug gene-therapy and external stenting to treat vein graft stenosis.


Professor Angelini is regarded a world leader in three major areas of translation research: development, evaluation and establishment into clinical practice of off-pump coronary artery bypass (OPCAB) surgery; systemic inflammatory response (SIR) to cardiopulmonary bypass (CPB) and cardioprotective strategies for myocardial preservation during heart surgery; and saphenous vein bypass graft failure.

Over the last ten years Professor Angelini has been at the forefront of the cardiac surgery community worldwide. The evidence he has provided from basic science, RCTs and observational studies using one of the first (1996) high quality cardiac surgery databases in the UK has led to significant changes in adult and paediatric cardiac surgery practice.


  • Saphenous vein bypass graft failure
  • Beating heart surgery
  • Arterial revascularisation
  • Mitral valve repair
  • Cardiac surgery


My main research interests include: Saphenous vein bypass graft failure; beating heart (off-pump) coronary surgery; arterial revascularisation; mitral valve repair. The introduction and development of beating heart surgery (1995-to date) has involved: i) technical innovations, the conduct of prospective randomised trials and monitoring of early and late patient outcomes, ii) published evaluation confirming reduction of in-hospital mortality and major economic benefits to the Health Service by the adoption of this technique, and iii) mentoring of surgeons in this country and abroad Cardiopulmonary bypass pathophysiology and myocardial protection in adult and pediatric heart surgery.

  • saphenous vein bypass graft failure
  • beating heart surgery
  • arterial revascularisation
  • mitral valve repair
  • cardiac surgery
  • Memberships


    Bristol Medical School (THS)

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