Dr Denize Atan

Summary

Learning and visual memory

Pattern separation

Neurogenetics

Neurodevelopment of the retina and brain

Neuro-inflammatory diseases of the eye and brain

Neuro-ophthalmology

Brain tumours

Biography

Denize completed her training in Clinical Medicine and Surgery at the University of Oxford (BM BCh) after first graduating from the University of Cambridge in Medical Sciences (MA Hons).  After specialising in general medicine and obtaining Membership of The Royal college of Physicians (MRCP UK), she became increasingly interested in the great variety of systemic diseases that affect the eye and vision in general.  Subsequently, she undertook further specialist training in ophthalmology in the South West region, including the Oxford Eye Hospital and Bristol Eye Hospital.

Denize completed her PhD in ocular genetics from the University of Bristol, followed by post-doctoral research funded by the Wellcome Trust at SickKids Hospital in Toronto, where she investigated the molecular genetics of retinal development.  She then completed her surgical training in ophthalmology with Membership followed by Fellowship of the Royal College of Ophthalmologists for which she received the Harcourt Medal on both occasions.  

Denize developed her clinical expertise in disorders that affect both the eye and the brain by completing a Senior Clinical Fellowship in Neuro-ophthalmology in Birmingham, one of the largest centres for neuro-ophthalmogy in the UK.  

Denize is currently President of the UK Eye Genetics Group: https://ukegg.com/ (with co-President Mariya Moosajee).

She works as a Senior Clinical Lecturer and Honorary Consultant in Neuro-ophthalmology at the Bristol Eye Hospital.  She is a member of the Bristol Vision Institute's management team. 

Activities / Findings

1. Impact of nutrition on vision

2. The impact of education on myopia

3. The rod bipolar transcriptome

4. Transcriptional regulators of development in the retina and brain.

5. Epilepsy and visual memory.

6. The influence of genetic variants on the severity and risk of intraocular inflammatory diseases.

Teaching

Denize is the Lead for Unit 5:"Diseases of the Nervous System" in the iBSc in Clinical Sciences course at the University of Bristol.

In addition, she teaches and lectures on the following courses:

1. Ophthalmology on the MB ChB programme, University of Bristol Medical School

2. Regenerative Medicine module, Cellular and Molecular Medicine

3. MSc in Stem Cells and Regeneration

Denize regularly supervises MSc research projects in Computer Science, Biomedical Sciences, Molecular Neuroscience and Regenerative Medicine.

She is qualified in teaching with a Certificate in Medical Education from the University of Bristol.

Keywords

• Neurogenetics
• Neurodevelopment
• Neurodegeneration
• Neuroinflammation Vision
• Memory.

Skills

• Alzheimer's Glaucoma Myopia Diabetes Brain Tumours Epilepsy

Processes and functions

• Development of visual function
• Development of the brain
• Inflammatory disorders of the eyes and brain
• Genetic disorders of the eyes and brain
• Neurodegenerative disorders of the eye and brain

Methodologies

• PCR
• RT-PCR
• ChIP
• RNA-seq
• MRI
• fMRI
• Immunohistochemistry
• Confocal imaging
• Behavioural testing
• Reporter assays.

Memberships

Organisations

Bristol Medical School (THS)

Academic staff

• School of Clinical Sciences Academic Staff
• CRICBristol

Research groupings

• Bristol Renal
• Diabetes and Metabolism
• Ophthalmology
• Stem Cells and Neuroregeneration Research Group
• Translational Neuroscience Research Group
• Dementia Research Group
• Multiple Sclerosis and Stem Cell Group
• Functional Neurosurgery
• Brain Tumour Research Centre
• Bristol Neuromuscular Research Group
• Clinical Neuroimaging and Neuroscience Research Group (CNNRG)
• Stroke Research Group

Links

• UK Eye Genetics Group

Recent publications

• Harrison, R, Warburton, V, Lux, A & Atan, D, 2019, ‘Blindness Caused by a Junk Food Diet’. Annals of Internal Medicine.
• Plotnikov, D, Shah, RL, Rodrigues, JN, Cumberland, PM, Rahi, JS, Hysi, PG, Atan, D, Williams, C, Guggenheim, JA & , 2019, ‘A commonly occurring genetic variant within the NPLOC4-TSPAN10-PDE6G gene cluster is associated with the risk of strabismus’. Human Genetics, vol 138., pp. 723-737
• Woods, SM, Mountjoy, E, Muir, D, Ross, SE & Atan, D, 2018, ‘A comparative analysis of rod bipolar cell transcriptomes identifies novel genes implicated in night vision’. Scientific Reports, vol 8.
• Atan, D, 2018, ‘BMJ Opinion: Education and myopia: assessing the direction of causality by mendelian randomisation’. BMJ.
• Atan, D, 2018, ‘Immunohistochemical phenotyping of mouse amacrine cell subtypes’. in: Mouse Retinal Phenotyping., pp. 237-248
• Mountjoy, E, Davies, NM, Plotnikov, D, Smith, GD, Rodriguez, S, Williams, CE, Guggenheim, JA & Atan, D, 2018, ‘Education and myopia: assessing the direction of causality by mendelian randomisation’. BMJ, vol 361.
• Mountjoy, E, Rodrigues, J, Yazar, S, Tideman, JWL, Rodriguez, S, Williams, CEM & Atan, D, 2017, ‘Genome-wide association study identifies genes associated with visual acuity in children’. in: Oxford-Bristol-Cardiff-Southampton Alliance in Vision Research.
• Mountjoy, E, Rodrigues, J, Yazar, S, Tideman, JWL, Rodriguez, S, Williams, CEM & Atan, D, 2017, ‘A genome-wide association study of visual acuity in children’. in: HUGO Human Genome Meeting.
• Kolaric, K, Woods, S, Ellis, C, Warburton, C, Bashir, Z & Atan, D, 2017, ‘The role of the dentate gyrus in visual object recognition memory’. in: Oxford-Bristol-Cardiff-Southampton Alliance in Vision Research.
• Márquez, A, Cordero-Coma, M, Martín-Villa, JM, Gorroño-Echebarría, MB, Blanco, R, Valle, DD, Rio, MJD, Blanco, A, Olea, JL, Cordero, Y, Capella, MJ, Díaz-Llopis, M, Ortego-Centeno, N, Ruiz-Arruza, I, Llorenç, V, Adán, A, Fonollosa, A, Berge, JT, Atan, D, Dick, AD, De Boer, JH, Kuiper, J, Rothova, A & Martín, J, 2017, ‘New insights into the genetic component of non-infectious uveitis through an Immunochip strategy’. Journal of Medical Genetics, vol 54., pp. 38-46

View complete publications list in the University of Bristol publications system

Networks & contacts

• Dr Neil Davies University of Bristol
• Professor George Davey Smith University of Bristol
• Professor Pat Kehoe University of Bristol
• Dr Zuner Bortolotto University of Bristol
• Professor Zafar Bashir University of Bristol
• Professor Clea Warburton University of Bristol
• Dr Conor Houghton University of Bristol
• Dr Mallar Chakravarty McGill University
• Dr Jason Lerch University of Oxford
• Dr Kathryn Urankar North Bristol NHS Trust
• Mr Mario Teo North Bristol NHS Trust
• Dr Cian O'Donnell University of Bristol
• Dr Marc Goodfellow University of Exeter
• Dr Marinho Lopes University of Cardiff
• Dr Jiaxiang Zhang University of Cardiff
• Professor Adam Zeman University of Exeter
• Professor Jeremy Guggenheim University of Cardiff
• Dr Cathy Williams University of Bristol
• Professor Julian Hamilton-Shield University of Bristol
• Dr Ella Hinton University of Bristol
• Dr Becky Foster University of Bristol
• Professor Andrew Dick University of Bristol
• Dr Claire Rice University of Bristol