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Professor Craig McArdle

Professor Craig McArdle

Professor Craig McArdle
B.Sc., Ph.D.(C.N.A.A.)

Professor of Molecular Pharmacology

Area of research

Cell signalling and reproductive endocrinology

Dorothy Hodgkin Building,
Whitson Street, Bristol BS1 3NY
(See a map)

Tel. +44 (0) 117 331 3077

Research summary

Fig 1 Compartmentalisation of N-terminal HA-tagged hGnRHR and XGnRHR in HeLa cellsOur research interests are in cell signalling and reproductive endocrinology. Most of our work focuses on the hypothalamic decapeptide GnRH, that acts via G-protein coupled receptors on pituitary gonadotrophs to mediate control of reproduction by the CNS. Type I mammalian GnRH receptors are unique in that they lack the C-terminal tails found in other G-protein coupled receptors, and much of our work has addressed the functional relevance of this distinction, placing emphasis on receptor desensitisation and internalisation as well as MAPK activation and receptor compartmentalisation (figure 1).

Most recent work exploits image-based readouts (e.g. fluorescent reporters) for activity of ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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