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Dr Anne-Marie O'Carroll

Dr Anne-Marie O'Carroll

Dr Anne-Marie O'Carroll
B.A. (Mod.), Ph.D.(Dub.)

Senior Research Fellow

Area of research

Neuroendocrine gene expression

Dorothy Hodgkin Building,
Whitson Street, Bristol BS1 3NY
(See a map)

Tel. +44 (0) 117 331 3042

Research summary

Our research interests are the molecular genetics and functional expression of neuropeptide G protein-coupled receptors. In mammals GPCRs form the most abundant superfamily of integral membrane proteins, and it has been estimated that ~50 % of all medicinal drugs act via binding to GPCRs. We are primarily interested in the mechanisms underlying the regulation of apelin receptor (APJ) and arginine vasopressin V1b receptor gene expression and activity in the cardiovascular system, the hypothalamo-neurohypophysial system (HNS) and the hypothalamic-pituitary-adrenal (HPA) axis.

APJ and its endogenous ligand apelin are expressed in the central nervous system (CNS) and act as regulators of central and ...

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Recent publications

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