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Professor Andrew Levy

Professor Andrew Levy

Professor Andrew Levy
B.Med.Sci, M.B.,B.S., Ph.D., F.R.C.P.

Emeritus Professor

Area of research

Pituitary adenoma pathogenesis and behaviour of normal pituitary tissue

Dorothy Hodgkin Building,
Whitson Street, Bristol BS1 3NY
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Fax. +44 (0) 117 331 3116
Tel. +44 (0) 117 331 3115

Research summary

Initially, the focus of research was to try and understand the pathogenesis of pituitary adenomas by analyzing differences in hormone gene expression and anomalies in second messenger transduction between human pituitary adenoma biopsies and normal rodent pituitary function 1-11. Over time it became clear that qualitative abnormalities are uncommon and that typical hallmarks of tumours such as proto-oncogene activation and tumour suppressor sequestration are almost invariably absent. I began to look at pituitary tumours as exuberant normality rather than benign malignancy. Having made that significant conceptual change, the question then became ‘how does the normal pituitary respond trophically to environmental ...

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