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Dr Alastair Wilkins

Dr Alastair Wilkins

Dr Alastair Wilkins
B.A., M.B.,B.Chir., Ph.D.(Cantab.)

Reader in Neurology

Area of research

Neuroprotectant therapies for chronic neurological diseases

Institute of Clinical Neurosciences, Lev,
Learning and Research Building, Southmead Hospital BS10 5NB
(See a map)

+44 (0) 117 41 47802

Summary

Dr Alastair Wilkins is Reader in Neurology, University of Bristol and Consultant Neurologist at Frenchay Hospital, Bristol.

He trained in medicine at Cambridge University, where he also did a PhD with Professor Alastair Compston concerned with mechanisms of axon degeneration in multiple sclerosis. His neurology training was in Norwich, Cambridge and the National Hospital for Neurology, Queen Square, London. He has done post-doctoral research at University of Cambridge and the University of Wisconsin- Madison, USA.

His main research interests are understanding disease mechanisms in progressive multiple sclerosis and design of new therapies for this stage of the disease. He also researches anti-oxidant properties of mesenchymal stem cells particularly in relation to cerebellar disorders including Friedreich's Ataxia.

He works closely with Prof Neil Scolding and collaborates with groups in University of Bristol and the University of Wisconsin- Madison, USA.

Activities / Findings

  • Developing therapies for progressive multiple sclerosis (MS Society Fellowship; Research and Development, North Bristol Trust Grant)
  • Degenerative ataxias and the potential for stem cell neuroprotection (Ataxia UK Grant)
  • Developing models of secondary progressive MS, particularly assays for axon survival

Teaching

  • Clinical Senior Lecturer for Neurology
  • Lecturer on Molecular Neuroscience Course
  • Clinical lectures to other health care professional and MS Society

Keywords

  • stem cells
  • PPAR
  • peroxisome
  • taiep rat
  • EAE.

Skills

  • Multiple sclerosis Friedreich's Ataxia

Processes and functions

  • Axon degeneration
  • anti-oxidant signalling
  • stem cell biology

Methodologies

  • Neuronal cell culture
  • immunohistochemistry
  • Western blots
  • RT-PCR
  • immunopathology

Expertise

My current projects are: ? Role of the peroxisome in axonal degeneration and progressive MS ? Degenerative ataxias and the potential for stem cell neuroprotection ? Developing a model of secondary progressive MS ? Developing Growth factor therapies for progressive multiple sclerosis

  • multiple sclerosis
  • axonal degeneration
  • degenerative ataxias
  • stem cell neuroprotection
  • progressive multiple sclerosis
  • Links

    Recent publications

    View complete publications list in the University of Bristol publications system

    Networks & contacts

    • Prof Neil Scolding (University of Bristol) Prof David Wraith (University of Bristol) Prof Ian Duncan (University of Wisconsin-Madison)

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