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Professor Dek Woolfson

Professor Dek Woolfson

Professor Dek Woolfson
BA(Oxon), PhD(Cantab)

Professor of Chemistry and Biochemistry

Area of research

Protein design and its application in bionanotechnology and synthetic biology

Office N410
Cantock's Close,
Clifton, Bristol BS8 1TS
(See a map)

Tel. +44 (0) 117 954 6347

Research summary

The primary basic research interest of the group is the informational aspect of the protein-folding problem; that is, how does the sequence of a protein determine its active, three-dimensional structure or fold?

We tackle this problem using the following multi-disciplinary approach:

  1. We use bioinformatics to garner sequence-to-structure relationships from protein sequence and structural databases.

  2. We test the relationships ("rules for protein folding") that we find in two ways: (a) through ab initio protein-structure prediction; and (b) via rational protein design, where we engineer natural protein structures, or design new ones completely from scratch (so-called de novo design).

  3. We then test ...

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Selected publications

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