Academic Staff
Professor Chris Paraskeva
Professor of Experimental Oncology
Contact Details
Dept. of Cellular & Molecular Medicine, University of Bristol,
School of Medical Sciences, Bristol, BS8 1TD
Tel: +44 (0)117 33 12072 (internal 12072)
Fax: +44 (0)117 33 12091
Email: c.paraskeva@bristol.ac.uk
Current Research
- Cell and Molecular Biology of Colorectal Cancer
- Control of cell growth, differentiation and apoptosis in colon
- Role of Bcl, Rb and APC
- Diet and cancer prevention
- NSAIDs (e.g., aspirin), butyrate, chemoprevention and apoptosis
- COX-2 selective NSAIDs and COX-2 regulation
Present co-workers
- Dr A. Williams, Reader
- Dr A. Hague, Oral & Dental Science
- Dr D. Qualtrough, Research Fellow
- Helena Smartt, Research Associate
- Alex Greenhough, Research Assistant
Recent Publications
Roth, U., Razawi, H., Hommer, J., Engelmann, K., Schwientek, T., Müller, S., Baldus, S.E., Patsos, G., Corfield, A.P., Paraskeva, C. and Hanisch, F.G. Differential expression proteomics of human colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma. Proteomics 2009 Nov 6. [Epub ahead of print]
Qualtrough, D., Singh, K., Banu, N., Paraskeva, C. and Pignatelli, M. (2009) The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro. Br. J. Cancer 101, 1124-1129.
Greenhough, A., Smartt, H.J., Moore, A.E., Roberts, H.R., Williams, A.C., Paraskeva, C. and Kaidi, A. (2009) The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 30(3), 377-386.
Ausch, C., Kim, Y.H., Tsuchiya, K.D., Dzieciatkowski, S., Washington, M.K., Paraskeva, C., Radich, J. and Grady, W.M. (2009) Comparative analysis of PCR-based biomarker assay methods for colorectal polyp detection from fecal DNA. Clin. Chem. 55, 1559-1563.
Moore, A.E., Greenhough, A., Roberts, H.R., Hicks, D.J., Patsos, H.A., Williams, A.C. and Paraskeva, C. (2009) HGF/Met signaling promotes PGE2 Biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. Carcinogenesis 30, 1796-1804.
Grady, W.M., Parkin, R.K., Mitchell, P.S., Lee, J.H., Kim, Y-H., Tsuchiya, K.D., Washington, M.K., Paraskeva, C., Willson, J.K.V., Kaz, A.M., Kroh, E.M., Allen, A., Fritz, B.R., Markowitz, S.D. and Tewari, M. (2008) Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene 27, 3880-3888.
Clemo, N.K., Collard, T.J., Southern, S., Edwards, K.D., Moorghen, M., Packham, G., Hague, A., Paraskeva, C. and Williams, A.C. (2008) BAG-1 is upregulated in colorectal tumour progression and promotes tumour cell survival through increasd NF-kappaB activity. Carcinogenesis 29, 849-857.
Varey, A.H., Rennel, E.S., Qiu, Y., Bevan, H.S., Perrin, R.M., Raffy, S., Dixon, A.R., Paraskeva, C., Zaccheo, O., Hassan, A.B., Harper, S.J. and Bates, D.O. (2008) VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy. Br. J. Cancer. 98, 1366-1379.
Kaidi, A., Moorghen, M., Williams, A.C. and Paraskeva, C. (2007) Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia? Gut 56, 1637-1638.
Banu, N., Buda, A., Chell., S., Elder, D., Moorghen, M., Paraskeva, C., Qualtrough, D. and Pignatelli M. (2007) Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy. Cell Proliferation 40, 768-779.
Greenhough, A., Patsos, H.A., Williams, A.C. and Paraskeva, C. (2007) The Cannabinoid Tetrahydrocannabinol, inhibits Ras-MAPK and PI3K- AKT survival signalling and induces BAD-mediated apoptosis in Colorectal Cancer Cells. Int. J. Cancer 121, 2172-2180.
Qualtrough, D., Kaidi, A., Chell, S., Jabbour, H.N., Williams, A.C. and Paraskeva, C. (2007) Prostaglandin F2 alpha stimulates motility and invasion in colorectal tumour cells. Int. J. Cancer 121, 734-740.
Kaidi, A., Williams, A.C., and Paraskeva, C. (2007) Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat. Cell Biol. 9(2), 210-217.
Kaidi, A., Qualtrough, D., Williams, A.C., and Paraskeva, C. (2006) Direct transcriptional upregulation of Cyclooxygenase-2 by Hypoxia-Inducible Factor (HIF)-1 promotes colorectal tumour cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res. 66, 6683-6691.
Chell, S.D. Witherden, I.R., Dobson, R.R., Moorghen, M., Qualtrough, D., Williams, A.C., and Paraskeva, C. (2006) Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence. Cancer Res. 66, 3106-3113.
Patsos, H.A., Hicks, D.J., Dobson, R., Greenhough, A., Woodman, N., Lane, J.D. Williams, A.C. and Paraskeva, C. (2005) The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells; a possible role for cyclooxygenase-2. Gut 54, 1741-1750.
Clemo, N.K., Arhel, N.J., Barnes, J.D., Moorghen, M., Packham, G., Paraskeva, C. and Williams, A.C. (2005) The role of the retinoblastoma protein (pRb) in the nuclear localisation of BAG-1: Implications for colorectal tumour cell survival. Biochem. Soc. Transact. 33, 676-678.
Hassan, A.B. and Paraskeva, C. (2005) Colorectal cancer prognosis: is it all mutation, mutation, mutation? Gut 54, 1209-1211.
Patsos, H.A., Hicks, D.J., Greenhough, A., Williams, A.C. and Paraskeva, C. (2005) Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem. Soc. Trans. 33, 712-714.
Chell, S., Patsos, H.A., Qualtrough, D., H-Zadeh, A.M., Hicks, D.J., Kaidi, A., Witherden, I.R., Williams, A.C. and Paraskeva, C. (2005) Prospects in NSAID-derived chemoprevention of Colorectal Cancer. Biochem. Soc. Trans. 33, 667-671.
Barnes, J.D., Arhel, N.J., Lee, S-S., Sharp, A., Al-Okail, M., Packham, G., Hague, A., Paraskeva, C. and Williams, A.C. (2005) Nuclear Bag-1 protects against radiation induced apoptosis in colorectal adenoma derived epithelial cells. Apoptosis 10, 301-311.
Hague, A., Hicks, D.J., Hasan, F., Smartt, H., Cohen, G.M., Paraskeva, C. and MacFarlane, M. (2005) Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis. Brit. J. Cancer 92, 736-742.
Hague, A. and Paraskeva, C. (2004) Apoptosis and disease: a matter of cell fate. Cell Death and Differentiation 11, 1366-1372.
Qualtrough, D., Buda, A., Gaffield, W., Williams, A. and Paraskeva, C. (2004) Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Int. J. Cancer 110, 831-837.
Smartt, H.J.M., Elder, D.J.E., Hicks, D.J., Williams, N.A. and Paraskeva, C. (2003) Increased NF-κB DNA-binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells. Brit. J. Cancer 89, 1358-1365.
Arhel, N.J., Packham, G., Townsend, P.A., Collard, T.J., H-Zadeh, A.M., Sharp, A., Cutress, R.I., Malik, K., Hague, A., Paraskeva, C. and Williams, A.C. (2003) The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines. Int. J. Cancer 106, 364-371.
Buda, A., Qualtrough, D., Jepson, M.A., Martines, D., Paraskeva, C. and Pignatelli, M. (2003) Butyrate downregulates α2 β1 integrin: a possible role in the induction of apoptosis in colorectal cancer cell lines. Gut 52, 729-734.
Collard, T.J., Guy, M., Butt, A.J., Perks, C.M., Holly, J.M.P., Paraskeva, C. and Williams, A.C. (2003) Transcriptional up-regulation of the insulin-like growth factor binding protein IGFBP-3 by sodium butyrate increases IGF-independent apoptosis in human colonic adenoma-derived epithelial cells. Carcinogenesis 24, 393-401.
Elder, D.J.E., Baker, J.A., Banu, N. A., Moorghen, M. and Paraskeva, C. (2002) Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression. J. Pathology 198, 428-434.
Playle, L.C., Hicks, D.J., Qualtrough, D. and Paraskeva, C. (2002) Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines. Br. J. Cancer 87, 352-358.
Qualtrough, D., Hinoi, T., Fearon, E. and Paraskeva, C. (2002) Expression of Cdx2 in normal and neoplastic human colon tissue and during the differentiation of an in vitro model system. Gut 51, 184-190.
Elder, D.J.E., Halton, D.E., Playle, L.C. and Paraskeva, C. (2002) The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. Int. J. Cancer 99, 323-327.