Academic Staff

Professor Anthony Hollander

ARC Professor of Rheumatology & Tissue Engineering

Contact Details
Dept. of Cellular & Molecular Medicine, University of Bristol,
School of Medical Sciences, Bristol, BS8 1TD
Tel: +44 (0)117 33 12403
Fax: +44 (0)117 33 12091
Email: A.Hollander@bristol.ac.uk

Head of Department

Current Research

Professor Anthony Hollander has been working in the field of cartilage biology and arthritis research for nearly 20 years, including 3 years spent at an internationally recognized cartilage laboratory at McGill University in Montreal. More recently he has focused on tissue engineering and stem cell biology for cartilage repair. He currently holds £1.7 million of peer-reviewed funding from research councils, EU framework 6, the Arthritis Research Campaign, The Wolfson foundation and from biotechnology companies. He has been the named inventor on several patents, including 2 currently being filed. He is the PI and project coordinator for a BBSRC/Smith & Nephew Link grant on the regulation of stem cell differentiation for cartilage repair. As part of an international collaboration funded by EU framework 5 he has pioneered the development of new assays and methodological approaches for the measurement of repair tissue quality in very small biopsies of cartilage from patients with knee injuries. He has raised the funding for an ultraclean laboratory facility that has now been built for engineered cartilage implant delivery to patients.

Adult stem cell breakthrough

Professor Hollander and his group have been involved in the first tissue-engineered trachea (windpipe), utilising a patient's own stem cells, that has been successfully transplanted into a young woman with a failing airway. The bioengineered trachea immediately provided the patient with a normally functioning airway, thereby saving her life. See: http://www.bristol.ac.uk/news/2008/6010.html

Present co-workers

Dr Wa'el Kafienah, Lecturer (Stem cell molecular biology)
Dr Sally C. Dickinson, Research Associate (Stem cell isolation)
Dr Sanjay Mistry, Research Associate
Mr Trevor J. Sims, Research Associate (Quantification of chondrogenesis)
Mr Henry Jia, Trainee Technician
Miss Kimberley Ridgway, PhD Student
Miss Catherine Sutton, PhD Student
Ms. Jan Cunningham, Business Manager
Mrs Jane Lohmann, Secretary

Recent Publications

Candrian, C., Vonwil, D., Barbero, A., Bonacina, E., Miot, S., Farhadi, J., Wirz, D., Dickinson, S., Hollander, A.P., Jakob, M., Li, Z., Alini, M., Heberer, M. and Martin, I. (2007) Engineered cartilage generated by nasal chondrocytes is responsive to physical forces resembling joint loading. Arthritis Rheum. [in press]

Marcacci, M., Kon, E., Zaffagnini, S., Filardo, G., Delcogliano, M., Neri, M.P., Iacono, F. and Hollander, A.P. (2007) Arthroscopic second generation autologous chondrocyte implantation. Knee Surg. Sports Traumatol. Arthrosc. 15, 610-619.

Kafienah, W., Mistry, S., Perry, M.J., Politopoulou, G. and Hollander, A.P. (2007) Pharmacological regulation of adult stem cells: chondrogenesis can be induced using a synthetic inhibitor of the retinoic acid receptor. Stem Cells 25, 2460-2468.

Kelly, D.J., Crawford, A., Dickinson, S.C., Sims, T.J., Mundy, J., Hollander A.P., Prendergast, P.J. and Hatton, P.V. (2007) Biochemical markers of the mechanical quality of engineered hyaline cartilage. J. Mater Sci.: Mater Med. 18, 273-281.

Kafienah, W., Mistry, S., Dickinson, S.C., Sims, T.J., Learmonth, I. and Hollander A.P. (2007) Three-dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients. Arthritis Rheum. 56, 177-187

Stewart, K., Pabbruwe, M., Dickinson, S., Sims, T., Hollander A.P. and Chaudhuri, J.B. (2007) The effect of growth factor treatment on meniscal chondrocyte proliferation and differentiation on polyglycolic acid scaffolds. Tissue Eng. 13, 271-280.

Farhadi, J., Fulco, I., Miot, S., Wirz, D., Haug, M., Dickinson, S.C., Hollander, A.P., Daniels, A.U., Pierer, G., Heberer, M. and Martin, I. (2006) Precultivation of engineered human nasal cartilage enhances the mechanical properties relevant for use in facial reconstructive surgery. Annals of Surgery 244, 978-985.

Hollander, A.P., Dickinson, S.C., Sims, T.J., Brun, P., Cortivo, R., Kon, E., Marcacci, M., Zanasi, S., Borrione, A., De Luca, C., Pavesio, A., Soranzo, C. and Abatangelo, G. (2006) Maturation and integration of tissue engineered cartilage implanted in injured and osteoarthritic human knees. Tissue Eng. 12, 1787-1798

Vats, A., Bielby, R.C., Tolley, N., Dickinson, S.C., Boccaccini, A.R., Hollander, A.P., Bishop, A.E. and Polak, J.M. (2006) Chondrogenic differentiation of human embryonic stem cells: the effect of the micro-environment. Tissue Eng. 12, p1687-1697.

Morgan, T.G., Rowan, A.D., Dickinson, S.C., Jones, D., Hollander, A.P., Deehan, D. and Cawston, T.E. (2006) Human Nasal Cartilage Responds to Oncostatin M in combination with IL-1 or TNF{alpha} by the Release of Collagen Fragments via Collagenases. Ann. Rheum. Dis. 65, 184-190.

Fraser, S.A., Crawford, A., Frazer, A., Dickinson, S.C., Hollander, A.P., Brook, I.M. and Hatton, P.V. (2006) Localisation of type VI collagen in tissue-engineered cartilage on polymer scaffolds. Tissue Eng. 12, 569-577.

Kafienah, W., Mistry, S., Williams, C. and Hollander, A.P. (2006) Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow. Stem Cells 24, 1113-1120.

Miot, S., Scandiucci de Freitas, P., Wirz, D., Daniels, A.U., Sims, T.J., Hollander, A.P., Mainil-Varlet, P., Heberer, M. and Martin, I. (2006) Cartilage tissue engineering by expanded goat articular chondrocytes. J. Orthop. Res. 24, 1078-1085.

Szebenyi, B., Hollander, A.P., Dieppe, P., Quilty, B., Duddy, J., Clarke, S. and Kirwan, J.R. (2006) Associations between pain, function, and radiographic features in osteoarthritis of the knee. Arthritis Rheum. 54, 230-235.

Dickinson, S.C., Sims, T.J., Pittarello, L., Soranzo, C., Pavesio, A. and Hollander, A.P. (2005) Quantitative outcome measures of cartilage repair in patients treated by tissue engineering. Tissue Eng. 11, 277-287.

Moretti, M., Wendt, D., Dickinson, S.C., Sims, T.J., Hollander, A.P., Kelly, D.J., Prendergast, P.J., Heberer, M. and Martin, I. (2005) Effects of in vitro pre-culture on the in vivo development of human engineered cartilage in an ectopic model. Tissue Eng. 11, 1421-1428.

Woodfield, T.B., Van Blitterswijk, C.A., De Wijn, J., Sims, T.J., Hollander, A.P. and Riesle, J. (2005) Abstract Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organisation within tissue-engineered cartilage constructs. Tissue Eng. 11, 1297-1311.

Iqbal, J., Bird, J.L., Hollander, A.P. and Bayliss, M.T. (2004) Effect of matrix depleting agents on the expression of chondrocyte metabolism by equine chondrocytes. Res Vet Sci. 77, 249-256.

Bilinghurst, R.C., Mwale, F., Hollander, A.P., Ionescu, M. and Poole, A.R. (2004) Immunoassays for Collagens in Chondrocyte and Cartilage Explant Cultures. Methods in Molecular Medicine, 100 Cartilage and Osteoarthritis, 1 Cellular & Molecular Tools. Totowa, NJ: Humana Press.

Hollander, A.P. and Hatton, P.V., Eds. (2004) Biopolymer methods in tissue engineering. (Methods in Molecular Medicine series). Totawa, NJ: Humana Press.

Dickinson, S.C., Vankemmelbeke, M.N., Buttle, D.J., Rosenberg, K., Heinegård, D. and Hollander, A.P. (2003) Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs. Matrix Biology 22, 267-278.

Hollander, A.P. (2003) Cartilage repair using cell and tissue transplants. In: The year in rheumatic disorders 2003, Eds. A. Cope, D. Scott. Oxford: CRC Press p242-242.

Mainil-Varlet, P., Aigner, T., Brittberg, M., Bullough, P., Hollander, A.P., Hunziker, E., Kandel, R., Nehrer, S., Pritzker, K., Roberts, S. and Stauffer, E. (2003) Histological assessment of cartilage repair. J. Bone & Joint Surgery 85A (Supp 2), 45-57.

Kafienah, W.Z., Al-Fayez, F., Hollander, A.P., Barker, M.D. (2003) Inhibition of cartilage degradation: A combined tissue engineering and gene therapy approach. Arthritis & Rheumatism 48, 709-718.

Hollander, A.P., Dickinson, S.C., Sims, T.J., Soranzo, C. and Pavesio, A. (2003) Quantitative analysis of repair tissue biopsies following chondrocyte implantation. In: Tissue engineering of cartilage and bone. Chichester: Wiley p218-229

Pavesio, A., Abatangelo, G., Biorrione, A., Brochetta, D., Hollander, A.P., Kon, E., Torasso, F., Zanasi, S. and Marcacci, M. (2003) Hyaluronan-based scaffolds (Hyalograft® C) in the treatment of knee cartilage defects: preliminary clinical findings. In: Tissue engineering of cartilage and bone. Chichester: Wiley p203-217.