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Professor Paolo Madeddu

Biography

Prof. P. Madeddu, is Chair of Experimental Cardiovascular Medicine and Head of the Section of Regenerative Medicine, School of Medicine, University of Bristol, where he relocated in 2005. He was previously Associate Professor at the Medical University of Sassari and Head of Gene Therapy Department at the Inter-University Consortium of Biosystems and Biostructures, Porto Conte Technological Park, Italy. He is Associate Editor for Circulation Research, ATVB, Pharmacology &Therapeutics and Regenerative Medicine. Previously, he was Associate Editor for the British Journal of Pharmacology.

Prof. Madeddu is recipient of several current and past grants on therapeutic angiogenesis, vasculogenesis and systems biology of bone marrow, funded by U.K., European and international organizations, including the Medical Research Council (MRC), the British Heart Foundation (BHF), the Wellcome Trust, the European Association of the Study of Diabetes (EASD), the Juvenile Diabetes Research Foundation (JDRF). He was and is a partner in the European FP6- and FP7-supported frameworks “EVGN” and “RESOLVE”.

Prof. Madeddu’s main interest is to develop new mechanistic therapies for the cure cardiovascular disease. He has 188 peer-reviewed publications in PubMed. His main contribution consists in the characterization of the role of kallikrein-kinin system in angiogenesis and vascular biology and of mechanisms implicated in the pathogenesis of diabetic microangiopathy. He discovered that a form of microangiopathy affecting the bone marrow of diabetic models and diabetic patients impairs stem cell homeostasis He also contributed in initial studies that led to the recognition of nerve growth factor as an angiogenic agent, a field that was then fully developed by Prof. Emanueli.

Prof. Madeddu is engaged in many protocols of angiogenesis gene therapy and cell therapy. His team set up a method for isolation and expansion of human pericyte progenitor cells. These cells showed a remarkable regenerative potential in model of ischemia and represent a valuable means for study the role of vascular supportive cells in different vascular pathologies.