The bulk of my research has focussed on Ca signalling in cardiac cells, but I have also developed experimental and computational methods that are widely used in other biomedical research. I am probably best known for the discovery of Ca sparks, which are fundamental to thinking about (cardiac) Ca signalling. In subsequent work we described how the stochastic nature of Ca spark production and ‘local control theories’ can explain the voltage- and time-dependence of the Ca transient (which I was the first measured in 1987 after developing real time fluorescent Ca measurement in single cells in 1985).
By measuring Ca ...
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