Professor Chris Willis

Research summary

Natural products isolated from bacteria, fungi and plants from both marine and terrestrial environments are a rich source of compounds of medicinal and agrochemical importance. We have published >130 papers which centre upon:-

• Structure elucidation and total synthesis of natural products
• Design and synthesis of probes to elucidate biosynthetic pathways and enzyme mechanisms
• Enantioselective synthesis of amino acids and heterocycles
• Isotopic labelling, biotransformations and reaction mechanisms

Professor Willis is a supervisor in the EPSRC Centre for Doctoral Training in Chemical Synthesis

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Links

• Willis Research Group

Recent publications

• Donnelly, B, Elliott, L, Willis, C & Booker-Milburn, K, 2019, ‘Sequential Photochemical and Prins Reactions for the Diastereoselective Synthesis of Tricyclic Scaffolds’. Angewandte Chemie - International Edition.
• Lees, NR, Han, L-C, Byrne, M, Davies, J, Parnell, A, Moreland, P, Stach, JEM, Kamp, MVd, Willis, C & Race, P, 2019, ‘An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis’. Angewandte Chemie - International Edition, vol 58., pp. 2305-2309

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View complete publications list in the University of Bristol publications system