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Professor Chris Willis
Professor Chris Willis
B.Sc.(Lond.), D.Phil.(Sus.)
Professor of Organic Chemistry
Area of research
Natural Products: Synthesis and Biosynthesis
Research summary
Natural products isolated from bacteria, fungi and plants from both marine and terrestrial environments are a rich source of compounds of medicinal and agrochemical importance. We have published >130 papers which centre upon:-
- Structure elucidation and total synthesis of natural products
- Design and synthesis of probes to elucidate biosynthetic pathways and enzyme mechanisms
- Enantioselective synthesis of amino acids and heterocycles
- Isotopic labelling, biotransformations and reaction mechanisms
Professor Willis is a supervisor in the EPSRC Centre for Doctoral Training in Chemical Synthesis
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Recent publications
- Connolly, JA, Wilson, A, Macioszek, M, Song, Z, Wang, L, Mohammad, HH, Yadav, M, Martino, Md, Miller, CE, Hothersall, J, Haines, AS, Stephens, ER, Crump, MP, Willis, CL, Simpson, TJ, Winn, PJ & Thomas, CM, 2019, ‘Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586’. Scientific Reports, vol 9.
- Szwalbe, AJ, Williams, K, Song, Z, De Mattos-Shipley, K, Vincent, JL, Bailey, AM, Willis, CL, Cox, RJ & Simpson, TJ, 2019, ‘Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi’. Chemical Science, vol 10., pp. 233-238
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