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Dr Stephen Soffe
Dr Stephen Soffe
Area of research
Neural control of motor responses in amphibian tadpoles
I work in close collaboration with Professor Alan Roberts, studying the neuronal circuitry of Xenopus locomotion. We use whole cell patch clamp to characterise individual neurons in sensory and motor pathways. In so doing we can understand the behaviour of a simple organism at a cellular level.
Activities / Findings
- Neural control of lower vertebrate locomotion
- Spinal inhibition
- Motor pattern selection
- Neural circuit flexibility
- L1 BIOL 12000 Life Processes (Neurobiology)
- L2 BIOL 20102 Neurobiology
- L3 BIOL 31127 Neuroethology
- whole-cell recording
- Spinal cord impairment
- basic information about neural circuit operation
Processes and functions
- patch clamp
- Buhl, E, Soffe, SR & Roberts, A, 2015, Sensory initiation of a co-ordinated motor response: Synaptic excitation underlying simple decision-making. Journal of Physiology (London), vol 593., pp. 4423-4437
- Hull, M, Soffe, SR, Willshaw, D & Roberts, A, 2015, Modelling Feedback Excitation, Pacemaker Properties and Sensory Switching of Electrically Coupled Brainstem Neurons Controlling Rhythmic Activity. PLoS Computational Biology, vol 12.
- Hull, M, Soffe, S, Willshaw, D & Roberts, A, 2015, Modelling the Effects of Electrical Coupling between Unmyelinated Axons of Brainstem Neurons Controlling Rhythmic Activity: Electrical Coupling via Unmyelinated Axons. PLoS Computational Biology, vol 11., pp. 1-26
- Roberts, A, Conte, D, Hull, M, Merrison-Hort, R, Azad, AKa, Buhl, E, Borisyuk, R & Soffe, SR, 2014, Can simple rules control development of a pioneer vertebrate neuronal network generating behavior?. Journal of Neuroscience, vol 34., pp. 608-621
- Soffe, S, Borisyuk, R, Azad, AKa, Conte, D & Roberts, A, 2014, A developmental approach to predicting brain connectivity from small biological datasets: a gradient-based neuron growth model: Neuron Growth Model and Neuronal Connectivity. PLOS ONE, vol 9., pp. 1-15
- Buhl, E, Roberts, A & Soffe, SR, 2012, The role of a trigeminal sensory nucleus in the initiation of locomotion. Journal of Physiology, vol 590., pp. 2453-2469
- Borisyuk, R, Azad, Aa, Conte, D, Roberts, A & Soffe, S, 2011, Modeling the connectome of a simple spinal cord. Frontiers in Neuroinformatics, vol 5:20.
- James, L & Soffe, S, 2011, Skin impulse excitation of spinal sensory neurons in developing Xenopus laevis (Daudin) tadpoles. Journal of Experimental Biology, vol 214(2)., pp. 3341 - 3350
- Roberts, A, Li, W-C & Soffe, S, 2010, How neurons generate behaviour in a hatchling amphibian tadpole: an outline. Front. Behav. Neurosci, vol 4:16.
- Berkowitz, A, Roberts, A & Soffe, S, 2010, Roles for multifunctional and specialized spinal interneurons in motor pattern generation: zebrafish, tadpoles, and turtles. Front. Behav. Neurosci, vol 4:36.
Networks & contacts
Prof Alan Roberts
- School of Biol. Sci.
- Univ. Bristol
Dr Mark Tunstall
- Structural Biology
- Univ. Otago
- New Zealand
Dr Steve Coombes
- Math. Sci.
- Loughborough Univ.
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