JEPRAS, R, PERKINS, E, RARITY, J, CARR, R, CLARKE, D & ATKINSON, T 1991, APPLICATION OF PHOTON-CORRELATION SPECTROSCOPY AS A TECHNIQUE FOR DETECTING CULTURE CONTAMINATION. Biotechnology and Bioengineering, vol 38., pp. 929-940
The application of photon correlation spectroscopy (PCS) to detect culture contamination in chemostats was studied. It was found that the presence of a given particle size in a population of particles of a different size could be detected, but this ability was strongly dependent on particle size difference and was most sensitive when contaminants are larger than the host. The inherent polydispersity of actively growing and dividing microbial cells negates any advantage in the use of multi-angle PCS to detect contaminants.