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Professor Patricia Kuwabara

Professor Patricia Kuwabara

Professor Patricia Kuwabara
B.A.(Johns Hopkins), Ph.D.(Penn.)

William P. Coldrick Chair in Genomics

Office M.3
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

+44 (0) 117 331 2126

Summary

My lab began using the nematode C. elegans as a multicellular animal model to understand the signalling pathway underlying cell fate decisions controlling sex determination. It was found that a signal transduction pathway, which shares homology with the Hedgehog/Patched (Hh/Ptc) signalling pathway, underlies sexual cell fate decisions. These studies have directly led to our present research interests: 1) The role of calpain proteases in cell signalling and degenerative processes and 2) the role of PTC and PTC-related proteins in cell proliferation and cytokinesis, and osmolarity regulation. We are also taking advantage of the local strengths at the University of Bristol in biochemical structural analysis by forging collaborations that take advantage of the genetic and cell biological tractability of C. elegans to explore the relationships between the structure and function of protein transporters and their effects on cell physiology

Biography

My lab used the nematode C. elegans as a model organism for biomedical studies. Our studies helped to establish that a signal transduction pathway sharing homology with the vertebrate Hedgehog/Patched (Hh/Ptc) signalling pathway underlies sexual cell fate decisions. These studies led to our current research on the role of PTC and PTC-related proteins in cell proliferation, osmolarity control and innate immunity. We are currently taking advantage of the local expertise at Bristol in mitochondrial biochemistry and using the genetic and cell biological tractability of C. elegans to explore the structure and function of mitochondrial protein transporters and their roles in lifespan extension. 

Teaching

Biochemistry: Cellular Composition

Recombinant DNA Technology

Gene Expression and Rearrangement

Cellular Information

Cell Biology of Development and Disease

 

 

Memberships

Organisations

School of Biochemistry

School of Biochemistry staff

Recent publications

View complete publications list in the University of Bristol publications system

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