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Professor Patricia Kuwabara

Professor Patricia Kuwabara

Professor Patricia Kuwabara
B.A.(Johns Hopkins), Ph.D.(Penn.)

William P. Coldrick Chair in Genomics

Office M.3
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

+44 (0) 117 331 2126


My lab began using the nematode C. elegans as a multicellular animal model to understand the signalling pathway underlying cell fate decisions controlling sex determination. It was found that a signal transduction pathway, which shares homology with the Hedgehog/Patched (Hh/Ptc) signalling pathway, underlies sexual cell fate decisions. These studies have directly led to our present research interests: 1) The role of calpain proteases in cell signalling and degenerative processes and 2) the role of PTC and PTC-related proteins in cell proliferation and cytokinesis, and osmolarity regulation. We are also taking advantage of the local strengths at the University of Bristol in biochemical structural analysis by forging collaborations that take advantage of the genetic and cell biological tractability of C. elegans to explore the relationships between the structure and function of protein transporters and their effects on cell physiology


Biochemistry: Cellular Composition

Recombinant DNA Technology

Gene Expression and Rearrangement

Cellular Information

Cell Biology of Development and Disease

Health Sciences: Biochemistry - Bristol Dental School




School of Biochemistry

School of Biochemistry staff

Recent publications

View complete publications list in the University of Bristol publications system

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