Professor Jo Adams

Research summary

The central interest of the laboratory is in cell-matrix adhesion processes and their roles in regulating intracellular signaling and cell protrusions. We study molecular mechanisms of these processes in health and disease. Research areas focus on extracellular processes that modulate extracellular matrix organization, also on intracellular signaling pathways that regulate actin cytoskeletal organisation in cell protrusions and adhesion complexes. More details of each area are given on the laboratory Group Page.

• Fascin-based protrusions and their role in carcinoma cell migration and metastasis: Current projects study signaling mechanisms that regulate actin-bundling by fascin in carcinoma cell migration and metastasis, examine how ...

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Biography

http://stke.sciencemag.org/cgi/content/full/sigtrans;11/532/eaar2566?ijkey=jXZLOKSXf3VlE&keytype=ref&siteid=sigtrans

Link to: Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction. 

https://rdcu.be/35VR

1981. B.A. Cantab (Natural Sciences, Biological) 1985. M.A. Cantab. 1987. Ph.D. University of London.

1987-1990. Post-doctoral researcher, Imperial Cancer Research Fund, London. (Laboratory of Fiona Watt).

1990-1991. EMBO Long Term Fellow and 1992-1994. HFSPO Long Term Fellow,  Vascular Research Division, Brigham and Women's Hospital, Harvard University. (Laboratory of Jack Lawler).

1994-2004 (held until 2002). Wellcome Trust Senior ...

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Links

• Jo Adams' Research group

Selected publications

• Rosini, S, Pugh, N, Bonna, AM, Hulmes, DJ, Farndale, RW & Adams, JC, 2018, ‘Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites’. Science Signaling, vol 11.
• Lommel, M, Strompen, J, Hellewell, AL, Balasubramanian, GP, Christofidou, ED, Thomson, AR, Boyle, AL, Woolfson, DN, Puglisi, K, Hartl, M, Holstein, TW, Adams, JC & Özbek, S, 2018, ‘Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction’. Scientific Reports, vol 8.

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Recent publications

• Dempsey, C, Bigotti, MG, Adams, J & Brancaccio, A, 2019, ‘Analysis of α-dystroglycan/LG domain binding modes: investigating protein motifs that regulate the affinity of isolated LG domains’. Frontiers in Molecular Biosciences, vol 6., pp. 1-19
• Shoemark, D & Adams, J, 2019, ‘Emergence of a Thrombospondin Superfamily at the Origin of Metazoans’. Molecular Biology and Evolution.

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View complete publications list in the University of Bristol publications system