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Publication - Dr Anna Chambers

    Chapter 11 – Variation, Modification, and Reorganization of Broken Chromatin

    Citation

    Chambers, A, Downs, J & Humphrey, T, 2016, ‘Chapter 11 – Variation, Modification, and Reorganization of Broken Chromatin’. in: Chromatin Signaling and Diseases. Academic Press, pp. 197-216

    Abstract

    DNA damage occurs in the context of chromatin, and, of course, so do recognition and repair of the DNA lesions. It is well established that chromatin composition and dynamics play a central role in the cellular response to DNA damage and, in particular, to double-strand breaks (DSBs). Here, we review recent advances in the contribution of histone posttranslational modifications, histone variants, and chromatin remodeling enzymes to DSB responses.

    Full details in the University publications repository