For the past two decades I have been fully and continuously engaged with clinical, laboratory and statistical aspects of genetic epidemiological population and family research studies. I recognise the syntheses of systems biology and hypothesis-driven research, and of combining technologies effectively into biomedical and translational research in order to better understand cardiovascular disease.
I qualified from the University of Oxford in 1980 with First Class Honours in Physiological Sciences and gained my medical degree with distinction from the University of Cambridge in 1982. My PhD, undertaken on an MRC Training Fellowship in the Department of Clinical Biochemistry in Cambridge, was in the protein chemistry, immunochemistry and molecular cloning of the protein PGP9.5 and its gene (UCHL1). I accredited in medical biochemistry and completed the MRCPath (in Chemical Pathology) in 1992. From 1992-1995 I held a BHF Intermediate Fellowship at UCLMS and from 1996-2000 was a Lister Institute Fellow. From 1997-2006 I was Professor of Human Genetics at the University of Southampton.
Since 1993 much of my research has been in the genetics of cardiovascular diseases and risk factors.
I have published over 150 original papers, 50 reviews and chapters, and edited 4 books. I have had almost continuous UK research funding from MRC since 1984 and BHF since 1992 and numerous other funding support ranging from building, JREI, SRIF and other infrastructure awards, to a range of focused project grants.
I served on BHF project grants panel for 4 years, am a member of MRC College of Experts, have served on UK Foresight panel and EU funding planning panels, am a member of numerous genetics advisory committees and also the MRC DNA Banking Network Oversight Committee, I am reviews editor for Human Genetics and on the editorial boards of Human Mutation, Frontiers in Genetics, International Journal of Molecular Epidemiology and Genetics and Clinical Laboratory.
I was head of the Division of Human Genetics (~150 staff and students) in Southampton Medical School for 6 years, where I also ran a group of 15-25 researchers for 9 years. I have taught medical biochemistry and genetics at BM, BSc, MSc and PhD/MD levels, and I was head of the postgraduate school of Southampton Medical School for 3 years.
I have also had experience of patents, IP and a small spin-out company.
Since 2007 I have been Deputy Director of the MRC Centre (Causal Analysis in Translational Epidemiology) at the University of Bristol. In addition to Bristol Genetic Epidemiology Laboratories, I also lead (since 2009) an MRC funded doctoral training programme in Systems Biomedicine (mathematical, statistical and computational approaches to medical research). I am a visiting professor at King Saud University, Riyadh, Saudi Arabia (invited 2010). I have been an external examiner for an MSc in Molecular Diagnostics (University of Nottingham, 2007-2009), for Final MB Clinical Pathology (University of Cambridge, 2007-2010) and for MRCPath (Genetics, 1997-present).
View complete publications list in the University of Bristol publications system
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