Directory of Experts
Details for Professor Julian Paton
| Personal details | |
| Name | Professor Julian Paton |
| Job title | Professorial Research Fellow in Physiology |
| Department | School of Physiology, Pharmacology & Neuroscience University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 331 8092 email: public-relations@bristol.ac.uk |
| Qualifications | B.Sc.(Birm.), Ph.D.(Lond.) |
| Professional details | |
| Keywords | central nervous system cardiovascular system respiratory system central nervous circuits autonomic dysfunction hypertension sleep apnoea neuronal mechanisms |
| Areas of expertise | Using a multidisciplinary approach we are studying the central nervous system control of cardiovascular and respiratory systems. These systems are controlled by common central nervous circuits to provide a matching of cardiac output and minute ventilation. Our aim is to identify novel mechanisms and targets that underpin autonomic dysfunction resulting in hypertension and sleep apnoea. Cardiovascular studies Our hypothesis is that the brain is to blame for hypertension. Primary hypertension is a worldwide epidemic. With an inability to restore normal blood pressure in ~50% of patients, we seek novel targets in central neuronal circuits regulating arterial pressure. Respiratory studies We are defining neuronal mechanisms generating breathing. Our hypothesis is that normal breathing (eupnea) is defined by synaptic interactions within a ponto-medullary circuit while gasping, caused by hypoxia that provides an autoresuscitation mechanism, is driven by medullary pacemaker neurones. |