Personal details |
Name |
Dr Keith
Brown |
Job title |
Reader in Molecular Pathology
|
Department |
School of Cellular and Molecular Medicine University of Bristol
|
Personal web page |
http://www.bristol.ac.uk/cellmolmed/research/cancer/brown.html |
Contact details |
This expert can be contacted via the University of Bristol Public Relations
Office.
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when contacting the Public Relations Office.
work+44 (0)117 331 8092
email: public-relations@bristol.ac.uk
|
Qualifications |
M.A.(Cantab.), M.Sc.(Birm.), Ph.D.(Birm.) |
Professional details |
Keywords |
molecular genetics
cancer
Wilms' tumour
neuroblastoma
epigenetics
|
Areas of expertise |
My research interests are in the molecular genetics of children's cancers, concentrating in particular on two common cancers; Wilms' tumour of the kidney and neuroblastoma, a cancer of the sympathetic nervous system.
§ Epigenetics of childhood cancers: The aim of this project is to characterize genome-wide DNA methylation changes in clinically important childhood cancers such as Wilms’ tumour and neuroblastoma. This is being achieved by the use of human promoter microarrays, hybridized with tumour DNA enriched for methylated sequences. § Novel loci involved in the development of Wilms' tumour
Positional cloning techniques have been used to map and identify the genes present at a novel chromosomal translocation at 7p involved in Wilm functional studies of these genes, as we have already developed for the WT1 gene.
§ Our work is supported by CLIC Sargent
|