Directory of Experts
Details for Dr Paul Race
| Personal details | |
| Name | Dr Paul Race |
| Job title | Reader in Biological Chemistry |
| Department | School of Biochemistry University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 331 8092 email: public-relations@bristol.ac.uk |
| Qualifications | BSc(Leeds), PhD(Birm.) |
| Professional details | |
| Keywords | structure function and engineering of polyketide synthases hybrid polyketide/non-ribosomal peptide antibiotics and anticancer drugs polyketide based cholesterol lowering agents |
| Areas of expertise | I am interested in natural products synthesised by the polyketide and related non-ribosomal peptide pathways. My research group employs a range of structural (X-ray crystallography, cryo-electron microscopy, NMR and solution scattering) and functional (enzyme kinetics, spectroscopy, etc.) methods to deconvolute, at the molecular level, the catalytic mechanisms of the individual component enzymes from selected synthetic pathways. These investigations form the basis of protein engineering approaches, where we seek to manipulate pathway enzymes to yield novel derivative products with improved therapeutic activities. Other areas of major interest include hybrid polyketide/non-ribosomal peptide antibiotics and anticancer drugs as well as polyketide based cholesterol lowering agents. |