Directory of Experts
Details for Dr Alexander Greenhough
| Personal details | |
| Name | Dr Alexander Greenhough |
| Job title | Senior Research Associate |
| Department | School of Cellular and Molecular Medicine University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 331 8092 email: public-relations@bristol.ac.uk |
| Qualifications | B.Sc.(Warw.), Ph.D.(Bristol) |
| Professional details | |
| Keywords | tumour cell survival colorectal cancer cell biology and chemoprevention hypoxia and the tumour microenvironment beta-catenin transcription factors apoptosis and autophagy HIF-1 COX-2, prostaglandins, NSAID and aspirin |
| Areas of expertise | Tumour cell survival mechanisms and colorectal cancer chemoprevention. Context-dependent roles for beta-catenin, HIF-1 and COX-2 during adaptive cellular responses to the hypoxic/hypoglycaemic tumour microenvironment. Genome-wide analysis of transcription factor binding sites and gene expression under conditions of cellular stress. Pleiotropic effects of COX-2/PGE2 signalling. Mechanisms underlying suppression of apoptosis and oncogene addiction. Regulation of BH3-only proteins by Raf-MEK-ERK1/2 and PI3K-Akt survival signalling cascades. Novel regulators of microenvironment-driven autophagy and its divergent roles in tumorigenesis. |