Directory of Experts
Details for Dr Domingo Tortonese
| Personal details | |
| Name | Dr Domingo Tortonese |
| Job title | Senior Lecturer in Anatomy |
| Department | Centre for Applied Anatomy University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 331 8092 email: public-relations@bristol.ac.uk |
| Qualifications | D.V.M., Dr.Vet.Sci.(LaPlata), Ph.D.(W.Virginia) |
| Professional details | |
| Keywords | fertility signal transduction pathways gonadotrophin releasing hormone gonadotrophin secretion temporal changes in fertility hypothalamus pituitary gland |
| Areas of expertise | My research focuses on the neuroendocrine regulation of fertility. The specific aim is to identify the signal transduction pathways and the neural, cellular and molecular mechanisms underlying the control of gonadotrophin releasing hormone (GnRH) and gonadotrophin secretion during naturally occurring temporal changes in fertility. To this end, my team has developed two complementary lines of research to investigate the regulation of GnRH neuronal networks within the hypothalamus, on one hand, and the paracrine interactions within the pituitary gland that may modulate the response of gonadotroph cells to GnRH stimulation on the other. The link between these two research lines is the participation of prolactin, a hormone that, in addition to its role during lactation, has been shown to negatively regulate the reproductive axis. |