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Details for Dr Jim Middleton

Personal details
Name Dr Jim Middleton
Job title Reader
Department Bristol Dental School University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
email:
Qualifications BSc(Bath), PhD(Leic)
Professional details
Membership of professional bodies FRCPath
Keywords chemokines
chemokine receptors
inflammatory disease
cell trafficking
endothelial cells
leukocytes
stem cells
Areas of expertise I am interested in the mechanism of leukocyte recruitment in inflammatory diseases, such as rheumatoid arthritis and periodontal disease. The focus is on chemokines and their receptors.

Research is in three main areas: 1) how chemokines are transported and presented by endothelial cells leading to leukocyte migration from the blood and into the tissue; 2)the chemokine receptors on leukocytes; 3) how stem cells migrate into inflamed tissues.