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Details for Professor Alastair Poole

Personal details
Name Professor Alastair Poole
Job title Professor of Pharmacology and Cell Biology
Department School of Physiology, Pharmacology & Neuroscience University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
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Qualifications VetMB, MA, PhD(Cantab), MRCVS
Professional details
Membership of professional bodies I am currently Deputy Chair of the Molecular & Cellular Board of the Medical Research Council (UK). I am also currently a Principal Editor for Platelets, and have been a committee member of the British Society for Haemostasis and Thrombosis, on the Editorial Advisory Board for the Journal of Thrombosis and Haemostasis and a full Editorial Board member for the Journal of Biological Chemistry.
Keywords Platelets
primary haemostatic system
pathological development of thrombosis
cell biology of platelets
protein kinases
platelet function
thrombus formation
Areas of expertise Platelets are the smallest cellular component of the blood and are an essential element in the primary haemostatic system. They are able to respond to a wide range of agonists and when activated at the site of blood vessel injury they rapidly aggregate to form a platelet haemostatic plug. Platelets are therefore of central importance in maintaining the physiological integrity of the vascular system and play a major role in the pathological development of thrombosis.

Our laboratory is interested in the cell biology of platelets, from the molecular through to the systems level. We are particularly interested in understanding how protein kinases may regulate platelet function and thrombus formation, and use a wide variety of techniques to address these questions.