My research interests are vulnerable atherosclerotic plaques and vein-graft failure and angioplasty restenosis.
Myocardial Infarction (MI) is caused by thrombosis superimposed on a ruptured or surface-eroded coronary atherosclerotic plaque.
We have contributed significant advances in understanding the role played by matrix degrading metalloproteinases in weakening the plaque extracellular matrix and the pathways that regulate their production. Similarly we are leading the world in understanding the molecular biology of vascular smooth muscle cells that repair such injuries.
More than half a million patients worldwide have a coronary artery bypass graft operation and more than twice that number have an angioplasty.
However, both procedures suffer from late failure due to renarrowing at the treatment site. We made a major contribution to the development of taxol-eluting intracoronary stents that have greatly reduced restenosis after angioplasty. We also developed a unique approach to prevent vein graft stenosis using an extravascular stent.