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Details for Dr Steven Burston

Personal details
Name Dr Steven Burston
Job title Senior Lecturer
Department School of Biochemistry University of Bristol
Personal web page http://www.bristol.ac.uk/biochemistry/research/sb.html
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
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Qualifications BSc (Hons), PhD
Professional details
Membership of professional bodies The Biochemical Society
American Association for the Advancement of Science (AAAS)
The Protein Society affiliated to Federation of American Societies for Experimental Biology (FASEB).
Keywords protein folding
molecular chaperones
molecular motors
Areas of expertise Proteins are the workforce of every cell and are synthesised by assembling amino acids in a particular sequence which is dictated by the genetic code of DNA. However, it is the folding of this string of amino acids into a unique three-dimensional shape which gives proteins their ability to function.

My research focuses on the molecular mechanisms of protein machines, termed molecular chaperones, which assist "protein quality control" within the biological cell i.e. they ensure that proteins are correctly folded in the right place at the right time, or alternatively that they are unfolded and degraded when necessary. This regulation of protein folding and degradation is essential for the survival of each cell. There are a number of diseases result in the malfunction of this system, which in turn may give rise to observed symptoms. Examples of these include BSE/CJD, Alzheimer's Disease, Huntington's Disease.
Media experience Interview on Radio 4 "Science Now" several years ago.