Directory of Experts

Details for Dr Fiona Holmes

Personal details
Name Dr Fiona Holmes
Job title Research Fellow
Teaching Fellow in Clinical Sciences
Department School of Physiology, Pharmacology & Neuroscience University of Bristol
Bristol Medical School (THS) University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office.

work+44 (0)117 331 8092
email:
Qualifications BSc, PhD (Kent)
Professional details
Keywords neuropathic pain
dorsal root ganglia
sensory neurons
glia
chemokines
galanin
Areas of expertise My main area of interest is to further understand the pathophysiology of neuropathic pain by studying the roles of factors that are differentially regulated in the dorsal root ganglion (DRG) following peripheral nerve damage. After injury to peripheral nerves there are changes in the expression of many factors - both in sensory neurons and non-neuronal cells (e.g. satellite glia and macrophages), that may contribute to the adaptive or maladaptive responses of the peripheral nervous sytem to injury, by modulating neuronal survival, regeneration and pain. I am particularly interested in the roles of chemokines, specifically CX3CL1, and the neuropeptide galanin. Much of my work is done in close collaboration with Prof David Wynick.