Directory of Experts

Details for Professor Adrian Mulholland

Personal details
Name Professor Adrian Mulholland
Job title Professor
Department School of Chemistry University of Bristol
Personal web page
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office.

work+44 (0)117 331 8092
Qualifications BSc(Bristol), DPhil(Oxon)
Professional details
Membership of professional bodies Royal Society of Chemistry
Keywords enzyme catalysis
quantum mechanics/molecular mechanics qm/mm methods
computational biochemistry
modelling biological molecules
drug design
drug metabolism
Areas of expertise Most biochemical reactions depend on enzyme catalysis, and understanding how enzymes 'work' at the molecular level is a fundamental problem. Enzymes are remarkably efficient and specific catalysts, but despite intensive experimental investigations, the detailed origins of their rate accelerations remain unclear. This question is of crucial importance in Biology, and also for the development of protein catalysts for practical applications. Better understanding is vital for analysing the activities of mutant or designed proteins, and for the design of inhibitors as pharmaceutical lead compounds in drug design. It also promises to contribute in predcitions of drug metabolism.
Media experience Interviews for BCFM radio, The Economist, Seed Magazine, RSC Chemistry World; also public lectures