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Details for Dr James Hodge

Personal details
Name Dr James Hodge
Job title Senior Lecturer
Department School of Physiology, Pharmacology & Neuroscience University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
email:
Qualifications BSc(Sheff), PhD(Cantab)
Professional details
Keywords plasticity
learning and memory
neurons
electrical activity
ion channels
synaptic changes
Drosophila
circadian rhythms
Areas of expertise I am interested in how activity and plasticity in the nervous system generates behaviour, particularly the role of voltage-gated potassium (Kv) channels, CamKII and CASK in these processes. We use Drosophila to study these protein families as they display high functional conservation with mammals and flies are highly genetically and experimentally tractable. We use electrophysiology or dynamic cell imaging to record neural activity from highly defined behavioural circuits that are complex enough to generate a repertoire of behaviours known to involve channels and interacting molecules in humans.
We are currently studying the role of several Kv channels and calcium signalling molecules in synaptic plasticity, learning, circadian rhythms and alcohol behaviours. We also use Drosophila to study molecular mechanisms of diseases involving Kv channels (channelopathies) and synaptic proteins (synaptopathies). To help model channelopathies in Drosophila we compare the electrophysiological and pharmacological properties of Drosophila Kv channels with their mammalian homologues.