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Details for Professor Stuart Mundell

Personal details
Name Professor Stuart Mundell
Job title Professor in Cellular Pharmacology
Department School of Physiology, Pharmacology & Neuroscience University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
email:
Qualifications BSc(Glas), PhD(Bristol)
Professional details
Keywords G protein-coupled receptors
protein
regulatory mechanisms
G protein-coupled receptor traffic
signalling pathways
receptor movement
receptor function
Areas of expertise G protein-coupled receptors (GPCRs), one of the largest protein families in the human genome, are the most tractable set of therapeutic targets for novel drug design. GPCRs are regulated in a dynamic and complex manner, and are not static entities inserted into the plasma membrane of cells. My research examines the regulatory mechanisms controlling GPCR traffic whilst assessing the impact of such mechanisms on signalling pathways that initiate important physiological responses. In order to examine these questions we use both biochemical and imaging techniques to study receptor movement and function.

Presently we are examining the regulation of P2Y1 and P2Y12 purinergic receptors in human platelets. Platelets are an essential element in the pathophysiology of heart disease. Adenosine diphosphate (ADP), which influences platelet adhesiveness and induces platelet aggregation, is recognised as one of the most important mediators of haemostasis and thrombosis.