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Details for Professor David Sheppard

Personal details
Name Professor David Sheppard
Job title Professor of Physiology
Department School of Physiology, Pharmacology & Neuroscience University of Bristol
Personal web page http://www.bris.ac.uk/phys-pharm/people/person/16933/
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
email:
Qualifications BSc(Brad), PhD(Cantab)
Professional details
Membership of professional bodies The Physiological Society
The Society of General Physiologists
The Biophysical Society
The European Cystic Fibrosis Society
Keywords cystic fibrosis
CFTR
chloride ion channels
epithelial ion transport
drug therapy
Areas of expertise I investigate the cystic fibrosis transmembrane conductance regulator (CFTR), the protein product of the gene defective in cystic fibrosis. CFTR is found in cells that line ducts and tubes within the body. It provides a pathway for salt movement and controls the quantity and composition of fluids in ducts and tubes. In my studies of CFTR, I have three specific research goals:
(i) To understand the relationship between CFTR structure and its role in salt movements.
(ii) To learn how genetic defects that cause CF disrupt CFTR function.
(iii) To identify new regulators of CFTR that might prove to be of value in the treatment of disease.
This research is important for understanding how salt and water are transported. This knowledge might lead to better drugs to treat cystic fibrosis and related diseases.