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Details for Dr Domingo Tortonese

Personal details
Name Dr Domingo Tortonese
Job title Senior Lecturer in Anatomy
Department Centre for Applied Anatomy University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
Qualifications DVM, DrVetSci(LaPlata), PhD(WVirginia)
Professional details
Keywords fertility
signal transduction pathways
gonadotrophin releasing hormone
gonadotrophin secretion
temporal changes in fertility
pituitary gland
Areas of expertise My research focuses on the neuroendocrine regulation of fertility. The specific aim is to identify the signal transduction pathways and the neural, cellular and molecular mechanisms underlying the control of gonadotrophin releasing hormone (GnRH) and gonadotrophin secretion during naturally occurring temporal changes in fertility. To this end, my team has developed two complementary lines of research to investigate the regulation of GnRH neuronal networks within the hypothalamus, on one hand, and the paracrine interactions within the pituitary gland that may modulate the response of gonadotroph cells to GnRH stimulation on the other. The link between these two research lines is the participation of prolactin, a hormone that, in addition to its role during lactation, has been shown to negatively regulate the reproductive axis.