| Unit name | Haemopoietic Stem Cell Transplantation |
|---|---|
| Unit code | PANM33006 |
| Credit points | 20 |
| Level of study | H/6 |
| Teaching block(s) |
Teaching Block 4 (weeks 1-24) |
| Unit director | Professor. Steward |
| Open unit status | Not open |
| Pre-requisites |
PANM22041 Infection and Immunity PANM22042 Cellular & Molecular Pathology MOLG22100 Recombinant DNA Technology MOLG22200 Gene Expression and Rearrangement. FMVS20001 Biomedical Research, Employability and Enterprise Skills |
| Co-requisites |
3 from level 6/H lecture units and Research Skills unit. |
| School/department | School of Cellular and Molecular Medicine |
| Faculty | Faculty of Life Sciences |
The most tangible evidence of advances in genetic, protein and cellular sciences is seen in haemopoietic stem cell transplantation. From early attempts at bone marrow transplantation, this has broadened to include the use of stem cells mobilised by growth factors from the donor's marrow into their bloodstream, cord blood and mesenchymal stem cells. Genetic advances have revolutionised the speed and accuracy of tissue typing, the assessment of engraftment and graft rejection, accurate quantitation of malignant cells and early detection of viral infections. Advances in antibody technology now allow the accurate selection of stem cells and of cells capable of fighting specific viral infections. This topic examines the biology of stem cells and the technology behind these advances, focussing particularly on how successful research in this School has been transferred from the laboratory to clinical application, bringing major benefits to clinical care. Lectures in weeks 13-16.
Aims:
To bilaterally teach scientists how basic scientific innovation can be translated rapidly to improve clinical care, and intercalating medical students the importance of collaborative research with scientists in areas which can readily translate. The Bone Marrow Transplant Unit at Bristol Royal Hospital for Children and members of the School of Cellular and Molecular Medicine have a wide-ranging and internationally renowned expertise in translational science. Once students have been taught the basics of haemopoietic stem cell transplantation, this is used to enthuse them in the importance of translational science to best quality medical care.
Knowledge and Understanding of haemopoietic stem cell transplantation, its history and its therapeutic potential. Knowledge of the scientific literature pertaining to stem cell transplantation and an ability to evaluate this literature critically.
Lectures, Data Handling Session
Where possible the unit will include a visit to the NHS - Blood and Transplant facilities in Filton.
Independent study: Students are expected to study the recommended literature.
Summative 3 hour written exam, to include 3 essays chose from 6.
Reviews and primary articles from the current scientific literature.
