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Unit information: Gene expression and rearrangement in 2024/25

Please note: Programme and unit information may change as the relevant academic field develops. We may also make changes to the structure of programmes and assessments to improve the student experience.

Unit name Gene expression and rearrangement
Unit code MOLG22200
Credit points 20
Level of study I/5
Teaching block(s) Teaching Block 1 (weeks 1 - 12)
Unit director Dr. van Aelst
Open unit status Not open
Units you must take before you take this one (pre-requisite units)

None. However, some prior knowledge of molecular biology (e.g. equivalent to the first year unit Biochemistry: Cellular Composition) is recommended.

Units you must take alongside this one (co-requisite units)

None

Units you may not take alongside this one

None

School/department School of Biochemistry
Faculty Faculty of Life Sciences

Unit Information

Why is this unit important?
The main aims of this unit are to provide students with a good understanding of (i) the mechanisms by which prokaryotic and eukaryotic cells replicate, repair and express their genetic material, and (ii) the importance of these processes in diseased and healthy cells. Further aims are to improve your ability to critically assess experimental data.


How does this unit fit into your programme of study?
The unit develops knowledge and understanding of the processes involved in maintaining and expressing the genetic material of microorganisms and animals.

Your learning on this unit

An overview of content
Topics covered in this unit include:

  • DNA-protein interactions
  • Mechanisms of DNA replication
  • Recombination and repair
  • Generation of immune diversity by rearrangement of immunoglobulin genes
  • Eukaryotic and prokaryotic gene expression and protein synthesis
  • Regulatory RNA
  • Viruses and cancer.

How will students, personally, be different as a result of the unit?
After engaging with the unit, students should understand, and be able to explain:

  1. how and why proteins interact with DNA.
  2. how DNA is replicated and repaired.
  3. the mechanisms of DNA recombination, and the importance of this process.
  4. how genes are transcribed and translated, and the mechanisms by which these processes can be controlled in prokaryotic and eukaryotic organisms.
  5. the molecular basis of oncogenes and DNA tumour viruses.
  6. the molecular basis of transposable elements.
  7. the regulatory roles of RNA.

Students should have acquired the skills necessary to:

  1. understand how to undertake experiments in molecular genetics.
  2. interpret experimental data relating to the processes described in the course.
  3. present experimental work in a clear and concise written report.

Learning Outcomes
Learning on this unit directly addresses components of the Bristol Skills Profile, including:

  • How to express my ideas.
  • How to think critically.
  • How to develop ideas and solve problems.
  • How to think creatively and innovatively.
  • How to analyse and present data.
  • Work well as part of a team.
  • Recognise and value the views and differences of others.
  • Able to identify and work with technological advances.

How you will learn

How you will learn (previously called Teaching Information)

Teaching in the unit is normally delivered through a combination of synchronous and asynchronous sessions, including lectures, workshops and laboratory classes.

How you will be assessed

Tasks which help you learn and prepare you for summative tasks (formative):

  • Essay writing workshops to help the development of essay writing: group feedback.
  • Data handling workshops which include exercises to help the development of data handling/interpretation: group feedback.

Tasks which count towards your unit mark (summative):

The components that make up the unit assessment are:

  • Practicals: 20%
  • Coursework essay: 10%
  • End of unit exam: 70%

To earn credit for this unit you must normally have made a reasonable attempt at each of the components of the unit assessment. A reasonable attempt requires a student to have undertaken the assessment activity and engaged with its purpose in the academic judgement of the relevant Unit Director, or nominee.


When assessment does not go to plan
Reassessment of the “Practical Assessments” component typically involves completion of one or more laboratory class assessments using model data.
For all other components, reassessment normally involves a second attempt at the same form of assessment.

Resources

If this unit has a Resource List, you will normally find a link to it in the Blackboard area for the unit. Sometimes there will be a separate link for each weekly topic.

If you are unable to access a list through Blackboard, you can also find it via the Resource Lists homepage. Search for the list by the unit name or code (e.g. MOLG22200).

How much time the unit requires
Each credit equates to 10 hours of total student input. For example a 20 credit unit will take you 200 hours of study to complete. Your total learning time is made up of contact time, directed learning tasks, independent learning and assessment activity.

See the University Workload statement relating to this unit for more information.

Assessment
The Board of Examiners will consider all cases where students have failed or not completed the assessments required for credit. The Board considers each student's outcomes across all the units which contribute to each year's programme of study. For appropriate assessments, if you have self-certificated your absence, you will normally be required to complete it the next time it runs (for assessments at the end of TB1 and TB2 this is usually in the next re-assessment period).
The Board of Examiners will take into account any exceptional circumstances and operates within the Regulations and Code of Practice for Taught Programmes.

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