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Unit information: Macromolecular Structure, Dynamics and Function in 2024/25

Please note: Programme and unit information may change as the relevant academic field develops. We may also make changes to the structure of programmes and assessments to improve the student experience.

Unit name Macromolecular Structure, Dynamics and Function
Unit code BIOC20002
Credit points 20
Level of study I/5
Teaching block(s) Teaching Block 4 (weeks 1-24)
Unit director Dr. Burston
Open unit status Not open
Units you must take before you take this one (pre-requisite units)

BIOC10002 – Biological Chemistry 1B
BIOC10003 – Biochemistry: Cellular Composition
BIOC10004 - Biochemistry: Cellular Processes

Units you must take alongside this one (co-requisite units)

BIOC20003 – Research Skills for Biochemists

Units you may not take alongside this one

None

School/department School of Biochemistry
Faculty Faculty of Life Sciences

Unit Information

Why is this unit important?
This unit examines the structures of soluble and integral membrane proteins, how this determines their function, their dynamics and how these are studied experimentally. This leads to understanding how cells extract energy from their surroundings, how energy is utilised to power molecular motors and how these are used to power dynamic cellular processes. The role of metalloenzymes in redox processes is also covered.


How does this unit fit into your programme of study?
The unit develops material introduced in Year 1 Biochemistry units. Study of the unit deepens understanding of physical biochemistry, structural biology and bioenergetics.

Your learning on this unit

An overview of content
Topics covered in this unit include:

Element 1: Protein Structure and Dynamics

  • Methods for determining macromolecular structures
  • Recombinant technology and protein engineering
  • Introduction to protein dynamics
  • Structure based drug design
  • Structural biology of membrane proteins
  • Structures and dynamics of transporters

Element 2: Molecular Motors

  • Kinesin motors
  • Myosin motors
  • Dynein motors
  • Helicases

Element 3: Powering Biological Systems

  • Proton-coupled redox reactions
  • Mitochondria and the production of ATP
  • Photosynthesis in plants and bacteria
  • The generation and detoxification of reactive oxygen species
  • Roles of redox reactions in biology

How will students, personally, be different as a result of the unit?

After engaging with the unit, students should be able to:

  1. Describe the application of recombinant engineering in protein science.
  2. Describe the basic principles of, and evidence for, protein dynamic motions.
  3. Explain the basic process of and issues surrounding structure-based drug design.
  4. Explain the challenges of membrane protein structural biology and how these can be overcome.
  5. Describe the key features of secondary transport.
  6. Explain how ATP is used to power diverse molecular motors and explain motor mechanisms.
  7. Explain how cells extract energy from their surroundings to form ATP.
  8. Describe the generation of reactive oxygen species and the mechanisms used by cells to detoxify them.
  9. Perform calculations based on protein purification and enzyme kinetics.
  10. Perform calculations based on protein purification, redox potential and solute transport.
  11. Describe relevant biochemical techniques used to investigate protein structure and dynamic function.
  12. Analyse and interpret experimental data from the study of protein structure and dynamic function.
  13. Use protein structure visualisation tools to analyse molecular structure/function relationships.

Learning Outcomes
Learning on this unit directly addresses components of the Bristol Skills Profile, including:

  • How to express my ideas and think critically.
  • How to develop ideas and solve problems.
  • How to think creatively and innovatively.
  • How to analyse and present data.
  • Work well as part of a team.
  • Confident in using digital tools.
  • Able to identify and work with technological advances.

How you will learn

Teaching in the unit is normally delivered through a combination of synchronous and asynchronous sessions, including lectures, data handling workshops and laboratory classes.

How you will be assessed

Tasks which help you learn and prepare you for summative tasks (formative):
Calculations workshops and practical reports provide practice and both individual and cohort feedback in preparation for the data handling and exam assessments. Workshops and worked examples of summative exam questions are also provided.

Tasks which count towards your unit mark (summative):
The components that make up the unit assessment are:

  • Practicals: 20%
  • Coursework assignment: 10%
  • Data Handling test: 10%
  • End of unit exam: 60%

To earn credit for this unit you must normally have made a reasonable attempt at each of the components of the unit assessment. A reasonable attempt requires a student to have undertaken the assessment activity and engaged with its purpose in the academic judgement of the relevant Unit Director, or nominee.


When assessment does not go to plan
Reassessment of the “Practical Assessments” component typically involves completion of one or more laboratory class assessments using model data.
For all other components, reassessment normally involves a second attempt at the same form of assessment.

Resources

If this unit has a Resource List, you will normally find a link to it in the Blackboard area for the unit. Sometimes there will be a separate link for each weekly topic.

If you are unable to access a list through Blackboard, you can also find it via the Resource Lists homepage. Search for the list by the unit name or code (e.g. BIOC20002).

How much time the unit requires
Each credit equates to 10 hours of total student input. For example a 20 credit unit will take you 200 hours of study to complete. Your total learning time is made up of contact time, directed learning tasks, independent learning and assessment activity.

See the University Workload statement relating to this unit for more information.

Assessment
The Board of Examiners will consider all cases where students have failed or not completed the assessments required for credit. The Board considers each student's outcomes across all the units which contribute to each year's programme of study. For appropriate assessments, if you have self-certificated your absence, you will normally be required to complete it the next time it runs (for assessments at the end of TB1 and TB2 this is usually in the next re-assessment period).
The Board of Examiners will take into account any exceptional circumstances and operates within the Regulations and Code of Practice for Taught Programmes.

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